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ESI 09

Cat. No. 4773 13 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Epac inhibitor
化学名： α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
纯度： ≥98% (HPLC)
说明书
引用文献 (13)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ESI 09

ESI 09 is an EPAC inhibitor. Inhibits EPAC-mediated insulin release from pancreatic β cells. Selective for EPAC over PKA. ESI 09 decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.

化合物库 for ESI 09

ESI 09 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ESI 09

分子量 330.77
公式 C16H15ClN4O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 263707-16-0
PubChem ID 6077765
InChI Key DXEATJQGQHDURZ-DEDYPNTBSA-N
Smiles CC(C)(C)C1=CC(C(/C(C#N)=N/NC2=CC=CC(Cl)=C2)=O)=NO1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ESI 09

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.08 100
ethanol 6.62 20

制备储备液 for ESI 09

以下数据基于产品分子量 330.77。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.12 mL 30.23 mL
5 mM 0.6 mL 3.02 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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产品说明书 for ESI 09

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ESI 09

参考文献是支持产品生物活性的出版物。

Almahariq et al (2013) A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol.Pharmacol. 83 122 PMID: 23066090

If you know of a relevant reference for ESI 09, please let us know.

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关键词: ESI 09, ESI 09 supplier, ESI09, EPAC, exchange, proteins, inhibitors, inhibits, GTPases, Rap, guanine, nucleotide, factor, cAMP, GEFI, 4773, Tocris Bioscience

13 篇 ESI 09 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ESI 09 的部分引用包括：

Derek C et al (2021) Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci 41 2883-2898 PMID: 33593853

Ginam et al (2021) β2-adrenergic receptor regulates ER-mitochondria contacts. Sci Rep 11 21477 PMID: 34728663

Cheng-Mao et al (2018) The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. J Biol Chem 293 717-730 PMID: 29158262

Jeremy F et al (2019) Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell 179 1289-1305.e21 PMID: 31761534

Siddharth et al (2019) Elevated glucose concentration in culture media decreases membrane trafficking of SGLT2 in LLC-PK1 cells via a cAMP/PKA-dependent pathway. Am J Physiol Cell Physiol 316 C913-C924 PMID: 30943059

Diana J et al (2019) Phospho-substrate profiling of Epac-dependent protein kinase C activity. Mol Cell Biochem 456 167-178 PMID: 30739223

Caglar et al (2019) Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype. J Immunol 203 3247-3255 PMID: 31722989

Chris et al (2020) Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. Elife 9 PMID: 33350386

Alyson E et al (2020) Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol 27 657-667.e6 PMID: 32220335

Perkins et al (2018) Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. Nat.Immunol. 19 1309 PMID: 30397349

Guichard et al (2017) Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog 13 e1006603 PMID: 28945820

Drelich et al (2018) Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells. Viruses 10 PMID: 30332733

Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation. EMBO Mol Med 11 2057 PMID: 26649942

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