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Submit ReviewEtazolate hydrochloride is a phosphodiesterase inhibitor, selective for PDE4 (IC50 = 2.0 μM).
分子量 | 325.8 |
公式 | C14H19N5O2.HCl |
储存 | Store at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 35838-58-5 |
PubChem ID | 37274 |
InChI Key | GQJUGJHJUZSJLZ-UHFFFAOYSA-N |
Smiles | CCN2C1=NC=C(C(OCC)=O)C(NN=C(C)C)=C1C=N2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Ahluwalia and Nicholson et al (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 12 19 PMID: 1848733
Chesin et al (1972) 1-Ethyl-4-(isopropylidenehydrazinol-H-pyrazolo-(3,4-b)-pyridin-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009) - potent new inhibitor of cyclic 3'5-nucleotide phosphodiesterase. Biochem.Pharmacol. 21 2443 PMID: 4345859
Rhoads (1982) Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction. Biochem.Pharmacol. 31 665 PMID: 6177320
关键词: Etazolate hydrochloride, Etazolate hydrochloride supplier, PDE4, inhibitors, inhibits, PDE, Phosphodiesterases, 0438, Tocris Bioscience
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