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Eticlopride hydrochloride

Cat. No. 1847 7 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： D2 and D3 antagonist (D3 > D2)
别名： (-)-Eticlopride
化学名： 3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamide hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (7)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Eticlopride hydrochloride

Eticlopride hydrochloride is a selective dopamine D2/D3 receptor antagonist (Ki values are 0.50 and 0.16 nM respectively). Antipsychotic.

技术数据 for Eticlopride hydrochloride

分子量 377.31
公式 C17H25ClN2O3.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 97612-24-3
PubChem ID 57266
InChI Key HFJFXXDHVWLIKX-YDALLXLXSA-N
Smiles O=C(C2=C(OC)C(Cl)=CC(CC)=C2O)NC[C@@H]1CCCN1CC.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Eticlopride hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 37.73 100

制备储备液 for Eticlopride hydrochloride

以下数据基于产品分子量 377.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.27 mL 1.33 mL 2.65 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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产品说明书 for Eticlopride hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Eticlopride hydrochloride

参考文献是支持产品生物活性的出版物。

Hall et al (1985) Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for DA-D2 receptors in the rat brain. Eur.J.Pharmacol. 111 191 PMID: 4018125

Giuliani and Ferrari (1997) Involvement of DA receptors in the antipsychotic profile of (-) eticlopride. Physiol.Behav. 61 563 PMID: 9108576

Claytor et al (2006) The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys. Pharmacol.Biochem.Behav. 83 456 PMID: 16631246

If you know of a relevant reference for Eticlopride hydrochloride, please let us know.

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关键词: Eticlopride hydrochloride, Eticlopride hydrochloride supplier, Selective, antagonists, D3, D2, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, (-)-Eticlopride, Non-selective, 1847, Tocris Bioscience

7 篇 Eticlopride hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Eticlopride hydrochloride 的部分引用包括：

Dorst et al (2020) Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun 11 5113 PMID: 33037215

Jensen (2015) Effects of DA D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas. PLoS One 10 e0146154 PMID: 26717015

Tønnesen et al (2011) Functional integration of grafted neural stem cell-derived DArgic neurons monitored by optogenetics in an in vitro Parkinson model. PLoS One 6 e17560 PMID: 21394212

Zhao et al (2014) Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats. Neuropsychopharmacology 38 256 PMID: 25379005

Kramar et al (2014) DA in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory. Int J Neuropsychopharmacol 39 1645 PMID: 24442095

Cassar et al (2015) A DA receptor contributes to paraquat-induced neurotoxicity in Drosophila. J Ginseng Res 24 197 PMID: 25158689

Burgess et al (2010) DArgic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33 1295 PMID: 21061851

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Effects of eticlopride on cue-induced reinstatement of food seeking.
By Kevin Ball on 01/22/2019
分析类型： In Vivo
种属： Rat

At a dose that did not alter responding during food self-administration (6.0 micrograms/kg), systemic injections of eticlopride significantly increased responding during cue-induced reinstatement of food seeking tests.

PMID: 21497172
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