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Exemestane

Cat. No. 3759 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3759 has been discontinued.

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说明： Steroidal aromatase (CYP19) inhibitor
别名： FCE 24304,EXE
化学名： 6-Methyleneandrosta-1,4-diene-3,17-dione
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Exemestane

Exemestane is an irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for Exemestane

Exemestane is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Exemestane

分子量 296.4
公式 C20H24O2
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 107868-30-4
PubChem ID 60198
InChI Key BFYIZQONLCFLEV-DAELLWKTSA-N
Smiles C[C@@]12C(C(C[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O)=C)=CC(C=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Exemestane

参考文献是支持产品生物活性的出版物。

Goss et al (2004) The steroidal aromatase inhibitor exeme. prevents bone loss in ovariectomized rats. Bone 34 384 PMID: 15003786

Wang and Chen (2006) Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor. Cancer Res. 66 10281 PMID: 17079446

Miller et al (2008) Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 13 829 PMID: 18695261

di Salle et al (1992) Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 43 137 PMID: 1525055

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关键词: Exemestane, Exemestane supplier, Pfizer, aromatase, inhibitors, inhibits, estrogen, synthesis, CYP19, Cytochrome, P450, FCE24304, FCE, 24304, EXE, 3759, Tocris Bioscience

1 篇 Exemestane 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Exemestane 的部分引用包括：

Adele M et al (2022) Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Sci Adv 8 eabo5633 PMID: 35921423

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