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exo-IWR 1

Cat. No. 3947 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3947 has been discontinued.

说明： Negative control for endo-IWR 1 (Cat. No. 3532)
化学名： 4-[(3aR,4R,7S,7aS-rel)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
纯度： ≥99% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for exo-IWR 1

exo-IWR 1 is a negative control for endo-IWR 1 25-fold less active than endo-IWR 1; exhibits decreased activity against the Wnt/β-catenin pathway.

Active Analog also available.

技术数据 for exo-IWR 1

分子量 409.44
公式 C25H19N3O3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 1127442-87-8
PubChem ID 1163034
InChI Key ZGSXEXBYLJIOGF-BTYSMDAFSA-N
Smiles O=C(NC5=CC=CC6=C5N=CC=C6)C(C=C4)=CC=C4N2C([C@@]1([H])[C@@H](C3)C=C[C@@H]3[C@]([H])1C2=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for exo-IWR 1

参考文献是支持产品生物活性的出版物。

Lu et al (2009) Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg.Med.Chem.Lett. 19 3825 PMID: 19410457

Chen et al (2008) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chem.Biol. 5 100

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关键词: exo-IWR 1, exo-IWR 1 supplier, endo-IWR, 1, endo-IWR1, negative, controls, Wnt, beta-catenin, b-catenin, β-catenin, Beta-catenin, 3947, Tocris Bioscience

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Pathways for exo-IWR 1

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.