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EXP 3174

Cat. No. 5728 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective AT1 antagonist
化学名： 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for EXP 3174

EXP 3174 is a potent and selective noncompetitive AT1 receptor antagonist (IC50 = 37 nM). Reduces blood pressure in a rat model. Active metabolite of Losartan potassium (Cat. No. 3798).

化合物库 for EXP 3174

EXP 3174 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for EXP 3174

分子量 436.89
公式 C22H21ClN6O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 124750-92-1
PubChem ID 108185
InChI Key ZEUXAIYYDDCIRX-UHFFFAOYSA-N
Smiles CCCCC1=NC(Cl)=C(C(O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EXP 3174

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.69 100
ethanol 43.69 100

制备储备液 for EXP 3174

以下数据基于产品分子量 436.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.44 mL 22.89 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.14 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for EXP 3174

参考文献是支持产品生物活性的出版物。

Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 255 211 PMID: 2213556

If you know of a relevant reference for EXP 3174, please let us know.

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关键词: EXP 3174, EXP 3174 supplier, EXP3194, losartan, carboxylic, acid, metabolite, hypertension, antihypertensive, AT1, antagonists, antagonism, angiotensin, II, potent, noncompetitive, selective, Angiotensin, Receptors, 5728, Tocris Bioscience

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