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Fasentin

Cat. No. 6100 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6100 has been discontinued.

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说明： GLUT1/GLUT4 inhibitor; also Fas-sensitizer
化学名： N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for Fasentin

Fasentin is a GLUT1 and GLUT4 inhibitor (IC50 = 68 μM). Preferentially inhibits GLUT4 over GLUT1. Sensitizes Fas receptor in a range of tumor cell lines (IC50 = 20 μM) by modulating the extrinsic apoptotic pathway downstream of TNF receptors but upstream of effector caspases.

技术数据 for Fasentin

分子量 279.64
公式 C11H9ClF3NO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 392721-37-8
PubChem ID 879520
InChI Key GNYIJZMBLZXJEJ-UHFFFAOYSA-N
Smiles CC(CC(NC1=CC(C(F)(F)F)=C(C=C1)Cl)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Fasentin

参考文献是支持产品生物活性的出版物。

Schimmer et al (2006) Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer.Res. 66 2367 PMID: 16489043

Wood et al (2008) A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol.Cancer.Ther. 7 3546 PMID: 19001437

Granchi et al (2016) Anticancer agents interacting with membrane glucose transporters. Med.Chem.Comm. 7 1716 PMID: 28042452

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关键词: Fasentin, Fasentin supplier, Fasentin, Inhibitors, Inhibits, Glucose, transporter, GLUT1, GLUT4, Fas-sensitizer, apoptosis, TNF, Transporters, 6100, Tocris Bioscience

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