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FC 11

Cat. No. 7306 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)
化学名： 1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1H-1,2,3-triazole-4-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FC 11

FC 11 is a highly potent focal adhesion kinase (FAK) PROTAC® Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

FAK antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4467 and MAB4467.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

技术数据 for FC 11

分子量 949.92
公式 C41H42F3N13O9S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2271035-37-9
PubChem ID 154723926
InChI Key RZKZQCHSKWKOAJ-UHFFFAOYSA-N
Smiles CN(S(C)(=O)=O)C1=C(C=CC=N1)CNC2=NC(NC3=CC=C(C=C3)NC(C4=CN(N=N4)CCOCCOCCNC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)=NC=C2C(F)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FC 11

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 94.99 100

制备储备液 for FC 11

以下数据基于产品分子量 949.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.05 mL 5.26 mL 10.53 mL
5 mM 0.21 mL 1.05 mL 2.11 mL
10 mM 0.11 mL 0.53 mL 1.05 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

Molarity Calculator

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参考文献 for FC 11

参考文献是支持产品生物活性的出版物。

Gao et al (2019) Design, synthesis, and evaluation of highly potent FAK-targeting PROTACs. ACS.Med.Chem.Lett. 11 1855 PMID: 33062164

If you know of a relevant reference for FC 11, please let us know.

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关键词: FC 11, FC 11 supplier, FC11, focal, adhesion, kinase, FAK, degrader, degrades, highly, potent, protac, proteolysis, targeting, chimera, targeted, protein, degradation, Focal, Adhesion, Kinase, Degraders, 7306, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia