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Febuxostat

Cat. No. 4427 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Xanthine oxidase inhibitor
别名： TEI 6720,TMX 67
化学名： 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Febuxostat

Febuxostat is a non-purine inhibitor of xanthine oxidase (Ki = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.

化合物库 for Febuxostat

Febuxostat is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Febuxostat

分子量 316.37
公式 C16H16N2O3S
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 144060-53-7
PubChem ID 134018
InChI Key BQSJTQLCZDPROO-UHFFFAOYSA-N
Smiles CC1=C(C(O)=O)SC(C2=CC(C#N)=C(OCC(C)C)C=C2)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Febuxostat

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.73 75
ethanol 15.82 50

制备储备液 for Febuxostat

以下数据基于产品分子量 316.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.75 mM 4.21 mL 21.07 mL 42.14 mL
3.75 mM 0.84 mL 4.21 mL 8.43 mL
7.5 mM 0.42 mL 2.11 mL 4.21 mL
37.5 mM 0.08 mL 0.42 mL 0.84 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Febuxostat

参考文献是支持产品生物活性的出版物。

Osada et al (1993) Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Eur.J.Pharmacol. 241 183 PMID: 8243554

Xu et al (2008) Xanthine oxidase inhibition with febux. attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. J.Card.Fail. 14 746 PMID: 18995179

Okamoto et al (2003) An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J.Biol.Chem. 278 1848 PMID: 12421831

If you know of a relevant reference for Febuxostat, please let us know.

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关键词: Febuxostat, Febuxostat supplier, TMX67, TEI6720, Febuxostat, xanthine, oxidase, oxidoreductase, inhibitors, inhibits, TEI, 6720, TMX, 67, Other, Oxygenases/Oxidases, 4427, Tocris Bioscience

2 篇 Febuxostat 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Febuxostat 的部分引用包括：

Konishi et al (2015) Febuxostat improves outcome in a rat model of cancer cachexia. Front Cell Neurosci 6 174 PMID: 26136193

Tremere et al (2009) OE shapes auditory processing in the adult brain by regulating inhibitory transmission and plasticity-associated gene expression. J Neurosci 29 5949 PMID: 19420261

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