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Felodipine

Cat. No. 2960 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2960 has been discontinued.

View all Ca<sub>V</sub>1.x Channels (L-type) products.
说明： CaV1.x blocker
化学名： 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Felodipine

Felodipine is a L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

化合物库 for Felodipine

Felodipine is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Felodipine

分子量 384.25
公式 C18H19Cl2NO4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 72509-76-3
PubChem ID 3333
InChI Key RZTAMFZIAATZDJ-UHFFFAOYSA-N
Smiles ClC1=C(Cl)C(C2C(C(OC)=O)=C(C)NC(C)=C2C(OCC)=O)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Felodipine

参考文献是支持产品生物活性的出版物。

Ljung (1990) Vascular selectivity of felodipine: experimental pharmacology. J.Cardiovasc.Pharmacol. 15 S11 PMID: 1693715

Furukawa et al (1999) Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 291 464 PMID: 10525060

Furukawa et al (2005) Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+ channel (α1G) expressed in Xenopus oocytes. J.Cardiovasc.Pharmacol. 45 241 PMID: 15725949

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关键词: Felodipine, Felodipine supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, Cav1.x, 2960, Tocris Bioscience

篇 Felodipine 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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Felodipine 的评论

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Felodipine used on Cav1.2 channels.
By Anonymous on 02/04/2019
种属： Human

Felodipine used on Cav1.2 channels to see the effect on blocking with increasing concentration and the underlying mechanism involved.

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