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Submit ReviewFenoldopam hydrochloride
说明： Selective D1-like partial agonist
别名： SKF 82526
化学名： 6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Fenoldopam hydrochloride
Fenoldopam hydrochloride is a selective D1-like dopamine receptor partial agonist (EC50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α2-adrenoceptor antagonist in vitro (Ki = 15 - 25 nM).
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
技术数据 for Fenoldopam hydrochloride
| 分子量 | 342.22 |
| 公式 | C16H16ClNO3.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 181217-39-0 |
| PubChem ID | 21642479 |
| InChI Key | NLMPGIXLXSPNFS-UHFFFAOYSA-N |
| Smiles | Cl.OC1=CC=C(C=C1)C1CNCCC2=C(Cl)C(O)=C(O)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Fenoldopam hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 3.06 | 10 |
制备储备液 for Fenoldopam hydrochloride
以下数据基于产品分子量 342.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.22 mL | 146.1 mL | 292.21 mL |
| 0.5 mM | 5.84 mL | 29.22 mL | 58.44 mL |
| 1 mM | 2.92 mL | 14.61 mL | 29.22 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
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产品说明书 for Fenoldopam hydrochloride
参考文献 for Fenoldopam hydrochloride
参考文献是支持产品生物活性的出版物。
Hahn et al (1982) Characterization of the peripheral and central effects of SK&F 82526, a novel DA receptor agonist. J.Pharmacol.Exp.Ther. 223 305 PMID: 6127401
Nichols et al (1990) The pharmacology of fenol. Am.J.Hypertens. 3 116S PMID: 1974439
Sibley et al (1982) Interactions of novel DArgic ligands with D-1 and D-2 DA receptors. Life Sci. 31 637 PMID: 6127585
If you know of a relevant reference for Fenoldopam hydrochloride, please let us know.
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关键词: Fenoldopam hydrochloride, Fenoldopam hydrochloride supplier, Selective, D1-like, partial, agonists, Dopamine, Receptors, D5, dopaminergic, SKF82526, GlaxoSmithKline, GSK, SKF, 82526, D1, and, 1659, Tocris Bioscience
1 篇 Fenoldopam hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Fenoldopam hydrochloride 的部分引用包括：
Chen et al (2013) Gastrin and D1 DA receptor interact to induce natriuresis and diuresis. Hypertension 62 927 PMID: 24019399
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.