主页 / 药理学 / Nuclear Receptors / LXR-like Receptors / LXR-like Receptor Agonists / Fexaramine

Fexaramine

Cat. No. 2563 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent, selective farnesoid X receptor (FXR) agonist
化学名： 3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid methyl ester
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Fexaramine

Fexaramine is a potent, selective farnesoid X receptor agonist (EC50 = 25 nM). Displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.

化合物库 for Fexaramine

Fexaramine is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Fexaramine

分子量 496.64
公式 C32H36N2O3
储存 Desiccate at +4°C
纯度 ≥97% (HPLC)
CAS Number 574013-66-4
PubChem ID 5326713
InChI Key VLQTUNDJHLEFEQ-KGENOOAVSA-N
Smiles O=C(C3CCCCC3)N(CC2=CC=C(C4=CC=C(N(C)C)C=C4)C=C2)C1=CC(/C=C/C(OC)=O)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Fexaramine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.66 100

制备储备液 for Fexaramine

以下数据基于产品分子量 496.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.14 mL
5 mM 0.4 mL 2.01 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for Fexaramine

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Fexaramine

参考文献是支持产品生物活性的出版物。

Nicolaou et al (2003) Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org.Biomol.Chem. 1 908 PMID: 12929628

Downes et al (2003) A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol.Cell 11 1079 PMID: 12718892

Pellicciari et al (2006) Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. J.Med.Chem. 49 4208 PMID: 16821780

If you know of a relevant reference for Fexaramine, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 LXR-like Receptor Agonists

关键词: Fexaramine, Fexaramine supplier, Potent, selective, farnesoid, X, receptor, FXR, agonists, Receptors, Liver, Farnesoid, LXR-like, 2563, Tocris Bioscience

1 篇 Fexaramine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Fexaramine 的部分引用包括：

Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. J Endocrinol 10 e0120295 PMID: 25811180

您是否知道使用了 Tocris Fexaramine 的优秀论文？ 请告知我们.

Fexaramine 的评论

目前没有该产品的评论。 Be the first to review Fexaramine and earn rewards!

Have you used Fexaramine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review