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Submit ReviewFG 7142
说明： Benzodiazepine inverse agonist
化学名： N-Methyl-β-carboline-3-carboxamide
纯度： ≥99% (HPLC)
生物活性 for FG 7142
FG 7142 is a benzodiazepine inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β-adrenoceptors in mouse cerebral cortex.
化合物库 for FG 7142
FG 7142 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for FG 7142
| 分子量 | 225.25 |
| 公式 | C13H11N3O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 78538-74-6 |
| PubChem ID | 4375 |
| InChI Key | QMCOPDWHWYSJSA-UHFFFAOYSA-N |
| Smiles | CNC(=O)C1=CC2=C(NC3=C2C=CC=C3)C=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for FG 7142
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. HCl | 16.89 | 75 | |
| DMSO | 22.52 | 100 |
制备储备液 for FG 7142
以下数据基于产品分子量 225.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.44 mL | 22.2 mL | 44.4 mL |
| 5 mM | 0.89 mL | 4.44 mL | 8.88 mL |
| 10 mM | 0.44 mL | 2.22 mL | 4.44 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.89 mL |
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产品说明书 for FG 7142
参考文献 for FG 7142
参考文献是支持产品生物活性的出版物。
Donner et al (1989) Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents. Naunyn Schmiedebergs Arch.Pharmacol. 340 352 PMID: 2478895
Knorr et al (1989) The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 495 355 PMID: 2765936
Stanford et al (1987) A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors. Eur.J.Pharmacol. 134 313 PMID: 3032657
Wettstei (1989) Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys. Eur.J.Pharmacol. 163 219 PMID: 2498110
If you know of a relevant reference for FG 7142, please let us know.
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关键词: FG 7142, FG 7142 supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, FG7142, 0554, Tocris Bioscience
4 篇 FG 7142 的引用文献
引用文献是使用了 Tocris 产品的出版物。 FG 7142 的部分引用包括：
Major et al (2009) The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta). J Neurosci 85 753 PMID: 19837095
Lukkes et al (2012) Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats. Physiol Behav 107 719 PMID: 22583860
Lukkes et al (2012) Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems. Brain Res 1443 1 PMID: 22297173
Johnson et al (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Life Sci 107 733 PMID: 22554617
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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