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Submit ReviewFIIN 1 hydrochloride
说明： Potent, irreversible FGFR inhibitor
化学名： N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide
纯度： ≥96% (HPLC)
生物活性 for FIIN 1 hydrochloride
FIIN 1 hydrochloride is a potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044).
技术数据 for FIIN 1 hydrochloride
| 分子量 | 693.06 |
| 公式 | C32H39Cl2N7O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥96% (HPLC) |
| CAS Number | 1256152-35-8 |
| PubChem ID | 90488902 |
| InChI Key | IQLGDXNKTDKSMY-UHFFFAOYSA-N |
| Smiles | CCN(CC)CCCCNC1=NC=C2C(N(CC3=CC=CC(NC(C=C)=O)=C3)C(N(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C2)=O)=N1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FIIN 1 hydrochloride
参考文献 for FIIN 1 hydrochloride
参考文献是支持产品生物活性的出版物。
Zhou (2010) A structure-guided approach to creating covalent FGFR inhibitors. Chem.Biol. 17 285 PMID: 20338520
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关键词: FIIN 1 hydrochloride, FIIN 1 hydrochloride supplier, FIIN1, hydrochloride, FGFR, fibroblast, growth, factors, receptors, irreversible, inhibits, inhibitors, PD173074, FGFR1, FGFR2, FGFR3, FGFR4, Flt-1, Flt-4, VEGFR2, 4002, Tocris Bioscience
1 篇 FIIN 1 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 FIIN 1 hydrochloride 的部分引用包括：
Ji Yeon et al (2013) Modulation of bevacizumab-induced toxicity for cultured human corneal fibroblasts. Invest Ophthalmol Vis Sci 54 3922-31 PMID: 23640039
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