FIN 56

Cat. No. 6280 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Ferroptosis activator

化学名： N²,N⁷-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (3)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for FIN 56

FIN 56 is a bifunctional inducer of ferroptosis in vitro. Activates squalene synthase (SQS) leading to coenzyme Q₁₀ depletion. Also induces degradation of glutathione peroxidase 4 (GPX4), via acetyl-CoA carboxylase (ACC).

化合物库 for FIN 56

FIN 56 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for FIN 56

分子量	517.66
公式	C₂₅H₃₁N₃O₅S₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1083162-61-1
PubChem ID	118986699
InChI Key	JLCFMMIWBSZOIS-UHFFFAOYSA-N
Smiles	ON=C1C2=CC(=CC=C2C2=CC=C(C=C12)S(=O)(=O)NC1CCCCC1)S(=O)(=O)NC1CCCCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FIN 56

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	51.77	100

制备储备液 for FIN 56

以下数据基于产品分子量 517.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.93 mL	9.66 mL	19.32 mL
5 mM	0.39 mL	1.93 mL	3.86 mL
10 mM	0.19 mL	0.97 mL	1.93 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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产品说明书 for FIN 56

分析证书/产品说明书

化学品安全技术说明书

参考文献 for FIN 56

参考文献是支持产品生物活性的出版物。

Shimada et al (2016) Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat.Chem.Biol. 12 497 PMID: 27159577

Cotto-Rios and Gavathiotis (2016) Chemical genetics: Unraveling cell death mysteries. Nat.Chem.Biol. 12 470 PMID: 27315536

If you know of a relevant reference for FIN 56, please let us know.

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查看全部 Ferroptosis Activators

关键词: FIN 56, FIN 56 supplier, FIN56, glutathione, peroxidase, 4, GPX4, activates, ferroptosis, activators, squalene, synthase, acetyl-CoA, carboxylase, ACC, Ferroptosis, Enzyme, Substrates, /, Activators, 6280, Tocris Bioscience

1 篇 FIN 56 的引用文献

引用文献是使用了 Tocris 产品的出版物。 FIN 56 的部分引用包括：

Jeff et al (2020) Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. Elife 9 PMID: 32686647

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for FIN 56

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.