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FIPI

Cat. No. 3600 7 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Phospholipase D inhibitor
化学名： N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (7)
评论 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FIPI

FIPI is a potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.

化合物库 for FIPI

FIPI is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for FIPI

分子量 457.93
公式 C23H24FN5O2.HCl
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1781834-93-2
PubChem ID 90488864
InChI Key BNMQCDOCYPGJJD-UHFFFAOYSA-N
Smiles O=C(N2)N(C3CCN(CCNC(C4=CC5=C(C=CC(F)=C5)N4)=O)CC3)C1=C2C=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FIPI

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 22.9 50

制备储备液 for FIPI

以下数据基于产品分子量 457.93。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.37 mL 21.84 mL 43.67 mL
2.5 mM 0.87 mL 4.37 mL 8.73 mL
5 mM 0.44 mL 2.18 mL 4.37 mL
25 mM 0.09 mL 0.44 mL 0.87 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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产品说明书 for FIPI

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for FIPI

参考文献是支持产品生物活性的出版物。

Monovich et al (2007) Optimization of halopemide for phospholipase D2 inhibition. Bioorg.Med.Chem.Lett. 17 2310 PMID: 17317170

Su et al (2009) 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol.Pharmcol. 75 43

If you know of a relevant reference for FIPI, please let us know.

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关键词: FIPI, FIPI supplier, potent, phospholipases, D, PLD1, PLD2, inhibitors, inhibits, esterases, Phospholipases, 3600, Tocris Bioscience

FIPI 的评论

平均评分: 5 (基于 2 条评论。)

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great product.
By Anonymous on 03/26/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： Hippocampal neuron

100 μM treat 45min

review image
used this drug as an inhibitor.
By Anonymous on 10/05/2017
分析类型： In Vitro
种属： Mouse
细胞系/组织： macrophages

Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation.

PMID: 27482714
review image