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说明： Cyclooxygenase-2 (COX-2) inhibitor
化学名： N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide
纯度： ≥98% (HPLC)
生物活性 for FK 3311
FK 3311 is a cyclooxygenase-2 (COX-2) inhibitor. Inhibits zymosan-induced prostaglandin E2 production by rat peritoneal neutrophils in vitro and adjuvant-induced arthritis in vivo. Anti-inflammatory.
技术数据 for FK 3311
| 分子量 | 341.33 |
| 公式 | C15H13F2NO4S |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 116686-15-8 |
| PubChem ID | 164009 |
| InChI Key | DIIYLGZNZGPXRR-UHFFFAOYSA-N |
| Smiles | FC1=CC(F)=CC=C1OC2=C(NS(=O)(C)=O)C=CC(C(C)=O)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FK 3311
参考文献 for FK 3311
参考文献是支持产品生物活性的出版物。
Tsuji et al (1992) Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxy-methanesulfonanilide derivatives. Chem.Pharm.Bull. 40 2399 PMID: 1446362
Otani et al (2007) Effects of the COX-2 inhibitor FK3311 on ischemia-reperfusion injury in the rat lung. J.Invest.Surg. 20 175 PMID: 17613692
Nakamura et al (1993) Studies on antiinflammatory agents. III. Synthesis and pharmacological properties of metabolites of 4'-acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide (FK3311). Chem.Pharm.Bull. 41
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关键词: FK 3311, FK 3311 supplier, Cyclooxygenase-2, COX-2, inhibitors, inhibits, Oxygenases, Oxidases, FK3311, Cyclooxygenase, 2776, Tocris Bioscience
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