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FK 866

Cat. No. 8072 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
化学名： (2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FK 866

FK 866 is a non-competitive and high-affinity inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by Etoposide (Cat. No. 1226) and Cisplatin (Cat. No. 2251).

技术数据 for FK 866

分子量 391.51
公式 C24H29N3O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 658084-64-1
PubChem ID 6914657
InChI Key KPBNHDGDUADAGP-VAWYXSNFSA-N
Smiles C(=O)(N1CCC(CCCCNC(/C=C/C=2C=CC=NC2)=O)CC1)C3=CC=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FK 866

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.15 100
ethanol 39.15 100

制备储备液 for FK 866

以下数据基于产品分子量 391.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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参考文献 for FK 866

参考文献是支持产品生物活性的出版物。

Hasmann et al (2003) FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res. 63 7436 PMID: 14612543

Travelli et al (2011) Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etop. or cisp. in neuroblastoma cells. J.Pharmacol.Exp.Ther. 338 829 PMID: 21685314

Galli et al (2008) Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. Chem.Med.Chem. 3 771 PMID: 18247435

If you know of a relevant reference for FK 866, please let us know.

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关键词: FK 866, FK 866 supplier, FK866, Nicotinamide, phosphoribosyltransferase, NMPRTase, inhibitors, inhibits, autophagy, apoptosis, NAD, NAMPT, potent, non-competitive, Apoptosis, Inducers, Autophagy, 8072, Tocris Bioscience

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FK 866 的评论

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FK 866.
By Anonymous on 12/19/2023
分析类型： In Vitro
种属： Human
细胞系/组织： RBE and HepG2

I used FK 866 in 10–50 nM concentrations for 24-72 hours and noted significant differences in cellular NAD level and cell growth.

Treat this drug for 72 hours for best results.

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