Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewFlavopiridol hydrochloride is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 - 25 nM and 84 - 200 nM for cdk9 and cdk2, respectively, and <0.85 μM for cdk1, cdk4, cdk5 and cdk7). Induces cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.
Flavopiridol hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
分子量 | 438.3 |
公式 | C21H20ClNO5.HCl |
储存 | Store at +4°C |
纯度 | ≥98% (HPLC) |
CAS Number | 131740-09-5 |
PubChem ID | 9910986 |
InChI Key | LGMSNQNWOCSPIK-LWHGMNCYSA-N |
Smiles | CN(CC3)C[C@@H](O)[C@H]3[C@]1=C(OC(C4=CC=CC=C4Cl)=CC2=O)C2=C(O)C=C1O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 43.83 | 100 | |
DMSO | 43.83 | 100 |
以下数据基于产品分子量 438.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.28 mL | 11.41 mL | 22.82 mL |
5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
参考文献是支持产品生物活性的出版物。
Kaur et al (1992) Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275. J.Natl.Cancer.Inst. 84 1736 PMID: 1279187
Ambrosini et al (2008) The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. Cancer Res. 68 2312 PMID: 18381438
Losiewicz et al (1994) Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275. Biochem.Biophys.Res.Comm. 201 589
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
If you know of a relevant reference for Flavopiridol hydrochloride, please let us know.
关键词: Flavopiridol hydrochloride, Flavopiridol hydrochloride supplier, L86-8275, HMR1275, cyclin, dependent, kinases, inhibitors, inhibits, CDKs, cell, cycle, arrest, antitumor, antiproliferative, anticancer, L, 86-8275, Cyclin-dependent, Kinase, Non-selective, 3094, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Flavopiridol hydrochloride 的部分引用包括:
Stork et al (2016) Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage. Elife 5 PMID: 27552054
您是否知道使用了 Tocris Flavopiridol hydrochloride 的优秀论文? 请告知我们.
目前没有该产品的评论。 Be the first to review Flavopiridol hydrochloride and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image