Flavopiridol hydrochloride

Pricing Availability   Qty
说明: Cdk inhibitor; potently inhibits cdk2 and cdk9
别名: L 86-8275
化学名: 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
纯度: ≥98% (HPLC)
说明书
引用文献 (1)
评论

生物活性 for Flavopiridol hydrochloride

Flavopiridol hydrochloride is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 - 25 nM and 84 - 200 nM for cdk9 and cdk2, respectively, and <0.85 μM for cdk1, cdk4, cdk5 and cdk7). Induces cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.

化合物库 for Flavopiridol hydrochloride

Flavopiridol hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Flavopiridol hydrochloride

分子量 438.3
公式 C21H20ClNO5.HCl
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 131740-09-5
PubChem ID 9910986
InChI Key LGMSNQNWOCSPIK-LWHGMNCYSA-N
Smiles CN(CC3)C[C@@H](O)[C@H]3[C@]1=C(OC(C4=CC=CC=C4Cl)=CC2=O)C2=C(O)C=C1O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Flavopiridol hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 43.83 100
DMSO 43.83 100

制备储备液 for Flavopiridol hydrochloride

以下数据基于产品分子量 438.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.41 mL 22.82 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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产品说明书 for Flavopiridol hydrochloride

参考文献 for Flavopiridol hydrochloride

参考文献是支持产品生物活性的出版物。

Kaur et al (1992) Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275. J.Natl.Cancer.Inst. 84 1736 PMID: 1279187

Ambrosini et al (2008) The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. Cancer Res. 68 2312 PMID: 18381438

Losiewicz et al (1994) Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275. Biochem.Biophys.Res.Comm. 201 589

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987


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关键词: Flavopiridol hydrochloride, Flavopiridol hydrochloride supplier, L86-8275, HMR1275, cyclin, dependent, kinases, inhibitors, inhibits, CDKs, cell, cycle, arrest, antitumor, antiproliferative, anticancer, L, 86-8275, Cyclin-dependent, Kinase, Non-selective, 3094, Tocris Bioscience

1 篇 Flavopiridol hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Flavopiridol hydrochloride 的部分引用包括:

Stork et al (2016) Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage. Elife 5 PMID: 27552054


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