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Submit ReviewFluoxetine hydrochloride
说明： 5-HT reuptake inhibitor
化学名： N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Fluoxetine hydrochloride
Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900-fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Fluoxetine also inhibits assembly and activation of the NLRP3-ASC inflammasome and prevents degeneration of retinal pigmented epithelium (RPE) cells in an animal model of dry age-related macular degeneration (AMD).
许可信息
Sold with the permission of Eli Lilly and Company
化合物库 for Fluoxetine hydrochloride
Fluoxetine hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Fluoxetine hydrochloride
| 分子量 | 345.78 |
| 公式 | C17H18F3NO.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 56296-78-7 |
| PubChem ID | 62857 |
| InChI Key | GIYXAJPCNFJEHY-UHFFFAOYSA-N |
| Smiles | Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Fluoxetine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 34.58 | 100 | |
| water | 3.46 | 10 |
制备储备液 for Fluoxetine hydrochloride
以下数据基于产品分子量 345.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.89 mL | 14.46 mL | 28.92 mL |
| 5 mM | 0.58 mL | 2.89 mL | 5.78 mL |
| 10 mM | 0.29 mL | 1.45 mL | 2.89 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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产品说明书 for Fluoxetine hydrochloride
参考文献 for Fluoxetine hydrochloride
参考文献是支持产品生物活性的出版物。
Beck et al (1997) Fluoxetine selectively alters 5-hydroxytryptamine1A and γ-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. J.Pharmacol.Exp.Ther. 281 115 PMID: 9103487
Benfield et al (1986) Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness. Drugs 32 481 PMID: 2878798
Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006
Chang et al (2010) Increased cellular turnover in response to fluox. in neuronal precursors derived from human embryonic stem cells. Int.J.Dev.Biol. 54 707 PMID: 19598107
Ambati et al (2021) Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration. Proc.Natl.Acad.Sci.USA 118 e2102975118 PMID: 34620711
If you know of a relevant reference for Fluoxetine hydrochloride, please let us know.
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关键词: Fluoxetine hydrochloride, Fluoxetine hydrochloride supplier, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, NLRP3, inflammasome, Neural, Stem, Cells, Inflammasomes, 0927, Tocris Bioscience
10 篇 Fluoxetine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Fluoxetine hydrochloride 的部分引用包括：
Zhang and Gaudry (2016) Functional integration of a serotonergic neuron in the Drosophila antennal lobe. Elife 5 PMID: 27572257
Sallin and Jazwinska (2016) Acute stress is detrimental to heart regeneration in zebrafish. Open Biol 6 PMID: 27030176
Kant et al (2018) Auto-Reactive Th17-Cells Trigger Obsessive-Compulsive-Disorder Like Behavior in Mice With Experimental Autoimmune Encephalomyelitis. Front Immunol 9 2508 PMID: 30429853
Pai et al (2015) Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation. J Neurosci 35 4366 PMID: 25762681
Silva et al (2014) Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion. PLoS One 9 e89641 PMID: 24586928
Kurita et al (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci 15 1245 PMID: 22864611
Nozawa et al (2009) TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci U S A 106 3408 PMID: 19211797
Hooper et al (2016) Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol 311 H572 PMID: 27371685
Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126
MacLean et al (2004) Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. J Pharmacol Exp Ther 109 2150 PMID: 15078799
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Fluoxetine hydrochloride 的评论
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Fluoxetine decreases cued fear recall in c57bl6J mice.
By
Olivia Hon on 05/23/2019
分析类型： In Vivo
种属： Mouse
10mg/kg fluoxetine hcl injected i.p. in male c57Bl6J mice before cued fear conditioning, significantly decreased freezing during fear recall 24 hours later
given 60 min before behavior, dissolved in.9% sterile saline
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.