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Submit ReviewFlurbiprofen
说明： Cyclooxygenase inhibitor
化学名： 2-Fluoro-α-methyl-[1,1'-biphenyl]-4-acetic acid
纯度： ≥99% (HPLC)
生物活性 for Flurbiprofen
Flurbiprofen is a potent inhibitor of cyclooxygenase (IC50 values are 0.1 and 0.4 μM for inhibition of human COX-1 and COX-2 respectively). Analgesic, anti-inflammatory and antipyretic in vivo. Inhibits tumor cell growth in vitro and in vivo. Regulates prostate stem cell antigen through activation of Akt kinase. Also inhibits fibroblast proliferation in vitro.
技术数据 for Flurbiprofen
| 分子量 | 244.26 |
| 公式 | C15H13FO2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 5104-49-4 |
| PubChem ID | 3394 |
| InChI Key | SYTBZMRGLBWNTM-UHFFFAOYSA-N |
| Smiles | CC(C(O)=O)C1=CC=C(C(F)=C1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Flurbiprofen
参考文献 for Flurbiprofen
参考文献是支持产品生物活性的出版物。
Gierse et al (1995) Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 305 479 PMID: 7832763
Glenn et al (1973) The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions 3 210 PMID: 4776365
Hoferova et al (2002) The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma. Cancer Invest. 20 490 PMID: 12094544
Zemskova et al (2006) Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase. Biochem.Pharmacol. 72 1257 PMID: 16949054
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关键词: Flurbiprofen, Flurbiprofen supplier, Cyclooxygenase, inhibitors, inhibits, COX, Oxidase, Oxygenases, Oxidases, stem, cells, Akt, kinases, Analgesics, anti-inflammatory, and, antipyretics, Stem, Cell, Signaling, 1769, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Flurbiprofen, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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