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Flutamide

Cat. No. 4094 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Non-steroidal androgen receptor antagonist
别名： SCH 13521
化学名： 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Flutamide

Flutamide is a non-steroidal antiandrogen; competitive antagonist of the androgen receptor. Blocks the biological activity of testosterone in vivo.

化合物库 for Flutamide

Flutamide is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Flutamide

分子量 276.21
公式 C11H11F3N2O3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 13311-84-7
PubChem ID 3397
InChI Key MKXKFYHWDHIYRV-UHFFFAOYSA-N
Smiles CC(C)C(NC1=CC(C(F)(F)F)=C([N+]([O-])=O)C=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Flutamide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.62 100
ethanol 27.62 100

制备储备液 for Flutamide

以下数据基于产品分子量 276.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.1 mL 36.2 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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产品说明书 for Flutamide

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Flutamide

参考文献是支持产品生物活性的出版物。

Sufrin and Coffey (1976) Flutamide. Mechanism of action of a new nonsteroidal antiandrogen. Invest.Urol. 13 429 PMID: 1270239

Butcher et al (2007) Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Res. 67 85 PMID: 17210686

Foster et al (2011) Drug safety is a barrier to the discovery and development of new androgen receptor antagonists. Prostate 71 480 PMID: 20878947

If you know of a relevant reference for Flutamide, please let us know.

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关键词: Flutamide, Flutamide supplier, androgen, receptors, antagonists, antiandrogen, nonsteroidal, SCH13521, chemotherapeutics, SCH, 13521, Androgen, Receptor, 4094, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Flutamide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

2 篇 Flutamide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Flutamide 的部分引用包括：

Y S et al (2019) Androgen Receptor-Mediated Regulation of Intracellular Calcium in Human Airway Smooth Muscle Cells. Cell Physiol Biochem 53 215-228 PMID: 31299143

Luis-Miguel et al (2020) The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge. J Neuroinflammation 17 37 PMID: 31992325

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