Formoterol hemifumarate

Cat. No. 1448 10 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective β₂ agonist

别名： BD 40A

化学名： (±)-(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide hemifumarate

纯度： ≥99% (HPLC)

引用文献 (10)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Formoterol hemifumarate

Formoterol hemifumarate is a potent, selective and long-acting β₂-adrenoceptor agonist. Displays 330-fold selectivity for β₂ over β₁ receptors (pK_d values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD₂ = 9.29), and is longer-acting and 100-fold more potent than Salbutamol (Cat. No. 0634).

化合物库 for Formoterol hemifumarate

Formoterol hemifumarate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Formoterol hemifumarate

分子量	402.45
公式	C₁₉H₂₄N₂O₄.½C₄H₄O₄
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	43229-80-7
PubChem ID	9832292
InChI Key	OBRNDARFFFHCGE-PERKLWIXSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].COC1=CC=C(C=C1)C[C@H](C)NC[C@@H](O)C1=CC(NC([H])=O)=C(O)C=C1.COC1=CC=C(C=C1)C[C@H](C)NC[C@@H](O)C1=CC(NC([H])=O)=C(O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Formoterol hemifumarate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO		50

制备储备液 for Formoterol hemifumarate

以下数据基于产品分子量 402.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.97 mL	24.85 mL	49.7 mL
2.5 mM	0.99 mL	4.97 mL	9.94 mL
5 mM	0.5 mL	2.48 mL	4.97 mL
25 mM	0.1 mL	0.5 mL	0.99 mL

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产品说明书 for Formoterol hemifumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Formoterol hemifumarate

参考文献是支持产品生物活性的出版物。

Anderson (1993) Formoterol: pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective β₂-adrenoceptor agonist bronchodilator. Life Sci. 52 2145 PMID: 8099696

Decker et al (1982) Effects of N-aralkyl substitution of β-agonists on α- and β-adrenoceptor subtypes: pharmacological studies and binding assays. J.Pharm.Pharmacol. 34 107 PMID: 6121868

Naline et al (1994) Relaxant effects and durations of action of formo. and salme. on the isolated human bronchus. Eur.Respir.J. 7 914 PMID: 7914176

If you know of a relevant reference for Formoterol hemifumarate, please let us know.

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10 篇 Formoterol hemifumarate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Formoterol hemifumarate 的部分引用包括：

McKeithan et al (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8 766 PMID: 29075196

Lavine et al (2013) Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism. JAMA Ophthalmol 131 376 PMID: 23303344

Bacou (2017) β2-adrenoreceptor stimulation dampens the LPS-induced M1 polarization in pig macrophages. Dev Comp Immunol 76 169 PMID: 28633932

Luo (2017) β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro. Scientific Reports 7 39905 PMID: 28051147

Lavine (2017) β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci 58 299 PMID: 28114591

Koziczak-Holbro et al (2019) Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies. J Pharmacol Exp Ther 369 188 PMID: 30819762

Pon et al (2016) The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J 30 1144 PMID: 26578688

Liu et al (2015) A long-acting β2-adrenergic agonist increases the expression of muscarine cholinergic subtype-3 receptors by activating the β2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells. Mol Cell Neurosci 11 4121 PMID: 25672589

Maupoil et al (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol 150 899 PMID: 17325650

Plummer et al (2004) Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines. BMC Cancer 4 93 PMID: 15603589

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