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Submit ReviewFPR A14
说明： FPR agonist
化学名： 1,3-Benzodioxolane-5-carboxylic acid 4'-benzyloxy-3'-methoxybenzylidene hydrazide
纯度： ≥99% (HPLC)
生物活性 for FPR A14
Formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 values are 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization respectively). Induces dose-dependent differentiation of mouse neuroblastoma N2a cells.
技术数据 for FPR A14
| 分子量 | 404.42 |
| 公式 | C23H20N2O5 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 329691-12-5 |
| PubChem ID | 5503194 |
| InChI Key | ULOKADSYVZOTTL-CFRMEGHHSA-N |
| Smiles | O=C(N/N=C\C3=CC=C(OCC4=CC=CC=C4)C(OC)=C3)C1=CC(OCO2)=C2C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FPR A14
参考文献 for FPR A14
参考文献是支持产品生物活性的出版物。
Schepetkin et al (2007) High-throughput screening for small molecule activators of neutrophils: Identification of novel N-formyl peptide receptor agonists. Mol.Pharmacol. 71 1061 PMID: 17229869
Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One 14 e0217815 PMID: 31170199
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关键词: FPR A14, FPR A14 supplier, Formyl, peptide, FPR, agonists, FPRA14, receptors, Peptide, Receptors, Cancer, Stem, Cell, Differentiation, 2826, Tocris Bioscience
2 篇 FPR A14 的引用文献
引用文献是使用了 Tocris 产品的出版物。 FPR A14 的部分引用包括：
Yan et al (2015) Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. J Hepatol 63 420 PMID: 25828472
Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One. 14 e0217815 PMID: 31170199
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