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Submit ReviewFR 122047 hydrochloride
说明： Cyclooxygenase (COX-1) inhibitor
化学名： 1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for FR 122047 hydrochloride
FR 122047 hydrochloride is a selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.028 and 65 μM for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo.
技术数据 for FR 122047 hydrochloride
| 分子量 | 459.99 |
| 公式 | C23H25N3O3S.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 130717-51-0 |
| PubChem ID | 196840 |
| InChI Key | YWMAVHIKOAOSFM-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC=C(C=C1)C1=C(N=C(S1)C(=O)N1CCN(C)CC1)C1=CC=C(OC)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FR 122047 hydrochloride
参考文献 for FR 122047 hydrochloride
参考文献是支持产品生物活性的出版物。
Dohi et al (1993) The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. Eur.J.Pharmacol. 243 179 PMID: 8276067
Ochi et al (2000) The analgesic effect profile of FR122047, a selective cyclo-oxygenase-1 inhibitor, in chemical nociceptive models. Eur.J.Pharmacol. 391 49 PMID: 10720634
Ochi and Goto (2002) Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. Br.J.Pharmacol. 135 782 PMID: 11834626
Tanaka et al (1994) Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles. J.Med.Chem. 37 1189 PMID: 8164261
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关键词: FR 122047 hydrochloride, FR 122047 hydrochloride supplier, Cyclooxygenase, COX-1, inhibitors, inhibits, Oxygenases, Oxidases, FR122047, hydrochloride, 1507, Tocris Bioscience
6 篇 FR 122047 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 FR 122047 hydrochloride 的部分引用包括：
Tunaru et al (2016) Arachidonic acid metabolite 19(S)-HETE induces vasorelaxation and platelet inhibition by activating prostacyclin (IP) receptor. PLoS One 11 e0163633 PMID: 27662627
Tunaru et al (2012) Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. PLoS One 109 9179 PMID: 22615395
Passafaro et al (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. J Virol 8 138 PMID: 22013477
Lu et al (2013) Aspirin minimized the pro-metastasis effect of sora. and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma. J Biol Chem 8 e65023 PMID: 23741443
Chia et al (2011) Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol 11 10 PMID: 21955547
Ray et al (2004) Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. Proc Natl Acad Sci U S A 78 12964 PMID: 15542648
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