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Submit ReviewFSL 1
说明： TLR2/6 agonist (also a putative TLR10 ligand)
纯度： ≥95% (HPLC)
生物活性 for FSL 1
FSL 1 is a TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.
技术数据 for FSL 1
| 分子量 | 1666.16 |
| 公式 | C84H140N14O18S |
| 序列 |
CGDPKHPKSF (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)propyl]-Cys) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 322455-70-9 |
| PubChem ID | 87858248 |
| InChI Key | VJJLLNHELGKSNA-YWKNMTRCSA-N |
| Smiles | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FSL 1
参考文献 for FSL 1
参考文献是支持产品生物活性的出版物。
Okusawa et al (2004) Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6. Infect.Immun. 72 1657 PMID: 14977973
Mauldin et al (2015) TLR2/6 agonists and IF.-gamma induce human melanoma cells to produce CXCL10. Int.J.Cancer 137 1386 PMID: 25765738
Le et al (2016) Stable toll-like receptor 10 knockdown in THP-1 cells reduces TLR-ligand-induced proinflammatory cytokine expression. Int.J.Mol.Sci. 17 E859 PMID: 27258267
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关键词: FSL 1, FSL 1 supplier, FSL1, TLR2/6, agonists, agonism, putative, TLR10, ligands, Toll-like, receptors, induces, inducers, TNF-α, TNF-alpha, TNF-a, tumor, tumour, necrosis, factor, NFκB, NFKB, HGF, Receptors, 6011, Tocris Bioscience
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平均评分: 5 (Based on 1 Review.)
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FSL-1 works well for inducing TLR2 signaling.
By
Xiaogang Wang on 09/15/2020
分析类型： In Vitro
种属： Human
细胞系/组织： THP-1
We used this molecule to serve as a control to induce TLR2 signaling. The differentiated THP-1 macrophages were treated with FSL-1 for staphylococcus aureus lipoproteins for 4 h and the TNFa in culture supernatants was measured by ELISA.
Pathways for FSL 1
