FSLLRY-NH2

Cat. No. 4751 9 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： PAR₂ peptide antagonist

纯度： ≥95% (HPLC)

引用文献 (9)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for FSLLRY-NH2

FSLLRY-NH2 is a selective PAR₂ peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch. FSLLRY-NH2 inhibits C. albicans induced inflammation in oral mucosal cells in vitro.

技术数据 for FSLLRY-NH2

分子量	796.97
公式	C₃₉H₆₀N₁₀O₈
序列	FSLLRY (Modifications: Tyr-6 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	245329-02-6
PubChem ID	73352412
InChI Key	KMSCNWHRNILNRJ-JNRWAQIZSA-N
Smiles	[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FSLLRY-NH2

溶解性	Soluble to 1 mg/ml in water

产品说明书 for FSLLRY-NH2

分析证书/产品说明书

化学品安全技术说明书

参考文献 for FSLLRY-NH2

参考文献是支持产品生物活性的出版物。

McLarty et al (2011) Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 58 264 PMID: 21730297

Chen et al (2011) Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in PacT.-induced neuropathic pain. Neuroscience 193 440 PMID: 21763756

Andoh et al (2012) Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J.Pharmacol.Exp.Ther. 343 91 PMID: 22761302

Kumar et al (2022) Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2. Front.Immunol. 13 912748 PMID: 35844627

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关键词: FSLLRY-NH2, FSLLRY-NH2 supplier, PAR2, protease, activated, receptors, selective, antagonists, Protease-Activated, Receptors, 4751, Tocris Bioscience