Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewFSLLRY-NH2
说明： PAR2 peptide antagonist
纯度： ≥95% (HPLC)
生物活性 for FSLLRY-NH2
FSLLRY-NH2 is a selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch. FSLLRY-NH2 inhibits C. albicans induced inflammation in oral mucosal cells in vitro.
技术数据 for FSLLRY-NH2
| 分子量 | 796.97 |
| 公式 | C39H60N10O8 |
| 序列 |
FSLLRY (Modifications: Tyr-6 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 245329-02-6 |
| PubChem ID | 73352412 |
| InChI Key | KMSCNWHRNILNRJ-JNRWAQIZSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for FSLLRY-NH2
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for FSLLRY-NH2
参考文献 for FSLLRY-NH2
参考文献是支持产品生物活性的出版物。
McLarty et al (2011) Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 58 264 PMID: 21730297
Chen et al (2011) Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in PacT.-induced neuropathic pain. Neuroscience 193 440 PMID: 21763756
Andoh et al (2012) Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J.Pharmacol.Exp.Ther. 343 91 PMID: 22761302
Kumar et al (2022) Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2. Front.Immunol. 13 912748 PMID: 35844627
If you know of a relevant reference for FSLLRY-NH2, please let us know.
按产品操作查看相关产品
关键词: FSLLRY-NH2, FSLLRY-NH2 supplier, PAR2, protease, activated, receptors, selective, antagonists, Protease-Activated, Receptors, 4751, Tocris Bioscience
9 篇 FSLLRY-NH2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 FSLLRY-NH2 的部分引用包括：
Xianglan et al (2019) Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects. J Allergy Clin Immunol 144 426-441.e3 PMID: 30872118
Noskovičová et al (2018) Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol 314 L695 PMID: 29351434
Nithin D et al (2020) Polarization of protease-activated receptor 2 (PAR-2) signaling is altered during airway epithelial remodeling and deciliation. J Biol Chem 295 6721-6740 PMID: 32241907
Peng et al (2016) Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2 Phil. Trans. R. Soc. B 371 1700 PMID: 27377732
White et al (2015) A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid P. Cell Death Dis 194 142 PMID: 25429068
Bao et al (2014) PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain. Mol Pain 10 28 PMID: 24886294
Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278
Kumar et al (2022) Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2. Front Immunl 13 912748 PMID: 35844627
Eum et al (2014) Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases. Am J Physiol Gastrointest Liver Physiol 306 G992 PMID: 24742991
您是否知道使用了 Tocris FSLLRY-NH2 的优秀论文？ 请告知我们.
FSLLRY-NH2 的评论
目前没有该产品的评论。 Be the first to review FSLLRY-NH2 and earn rewards!
Have you used FSLLRY-NH2?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image