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Submit ReviewFTI 276
说明： Farnesyltransferase (FTase) inhibitor; antitumor
化学名： N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt
纯度： ≥95% (HPLC)
生物活性 for FTI 276
Ras CAAX peptidomimetic, a selective inhibitor of farnesyltransferase (FTase) that displays > 100-fold selectivity over geranylgeranyltransferase I (GGTase I) (IC50 values are 0.5 and 50 nM respectively). Blocks growth of human lung carcinoma expressing oncogenic K-Ras in nude mice.
技术数据 for FTI 276
| 分子量 | 547.61 |
| 公式 | C21H27N3O3S2.C2HF3O2 |
| 储存 | Store at -80°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1217471-51-6 |
| PubChem ID | 395753 |
| Smiles | SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@](O)=O)CCSC)=O)C(C2=CC=CC=C2)=C1.FC(F)(C(O)=O)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FTI 276
参考文献 for FTI 276
参考文献是支持产品生物活性的出版物。
Sun et al (1995) Ras CAAX peptidomimetic FTI 276 selectively blocks tumour growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. Cancer Res. 55 4243 PMID: 7671229
Lerner et al (1995) Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling inducing cytoplasic accumulation of inactive Ras-Raf complexes. J.Biol.Chem. 270 26802 PMID: 7592920
Lerner et al (1995) Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J.Biol.Chem. 10 26770
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关键词: FTI 276, FTI 276 supplier, Ras, CAAX, peptidomimetic, inhibitors, inhibits, farnesyltransferase, FTase, geranylgeranyltransferase, GGTase, carcinoma, K-Ras, tumour, tumor, FTI276, Protein, Prenyltransferases, Post-translational, Modifications, 2406, Tocris Bioscience
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