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Submit ReviewPeptide agonist for galanin receptors, showing selectivity for GAL2 (Ki values are 85, 1.9 and 12.6 nM at rat GAL1, GAL2 and GAL3 receptors respectively).
分子量 | 3107.42 |
公式 | C139H207N42O40 |
序列 |
WTLNSAGYLLGPHAIDNHRSFSDKHGLT (Modifications: Thr-28 = C-terminal amide) |
储存 | Desiccate at -20°C |
CAS Number | 141696-11-9 |
PubChem ID | 90469976 |
InChI Key | ACSWKWWDLCUVJF-QTRPWDSUSA-N |
Smiles | [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Amiranoff et al (1989) Structural requirements for galanin action in the pancreatic β cell line rin m 5F. Eur.J.Pharmacol. 163 205 PMID: 2472967
Wang et al (1997) Cloning and expressional characterization of a novel galanin receptor. J.Biol.Chem. 272 31949 PMID: 9405385
Wang et al (1997) Molecular cloning and pharmacological characterization of a new galanin receptor subtype. Mol.Pharmacol. 52 337 PMID: 9281594
关键词: Galanin (2-29) (rat), Galanin (2-29) (rat) supplier, Selective, GAL2, GalR2, peptide, agonists, Receptors, Galanin, 1451, Tocris Bioscience
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.