Galidesivir dihydrochloride

Cat. No. 7229 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral

别名： BCX 4430

化学名： (2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol dihydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Galidesivir dihydrochloride

Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC₅₀ values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.

技术数据 for Galidesivir dihydrochloride

分子量	338.19
公式	C₁₁H₁₅N₅O₃.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1373208-51-5
PubChem ID	90008271
InChI Key	LOHGEHBUEDUIRK-PUSSMWDMSA-N
Smiles	NC1=NC=NC2=C1NC=C2[C@@H]3N[C@@H]([C@H]([C@H]3O)O)CO.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Galidesivir dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	33.82	100
	DMSO	16.91	50

制备储备液 for Galidesivir dihydrochloride

以下数据基于产品分子量 338.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.57 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.3 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.3 mL	0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Galidesivir dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Galidesivir dihydrochloride

参考文献是支持产品生物活性的出版物。

Li & De Clercq (2020) Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat.Rev.Drug Discov. 19 149 PMID: 32127666

Warren et al (2014) Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 508 402 PMID: 24590073

If you know of a relevant reference for Galidesivir dihydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 RNA Polymerase Inhibitors

关键词: Galidesivir dihydrochloride, Galidesivir dihydrochloride supplier, Broad, spectrum, antiviral, rna-dependent, rna, polymerase, inhibitors, inhibits, RdRP, BCX, 4430, RNA, Polymerase, Non-selective, Antivirals, Coronavirus, 7229, Tocris Bioscience

篇 Galidesivir dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Galidesivir dihydrochloride 的引用文献。您是否知道使用了 Tocris Galidesivir dihydrochloride 的优秀论文？请告知我们.