Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGarcinol
说明： PCAF/p300 inhibitor; anticancer
化学名： (1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione
纯度： ≥98% (HPLC)
生物活性 for Garcinol
Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are 5 and 7 μM, respectively). Promotes expansion of human HSCs ex vivo. Causes reversal of EMT and inhibits β-catenin in breast cancer cell lines MDA-MB-231 and BT-549.
技术数据 for Garcinol
| 分子量 | 602.8 |
| 公式 | C38H50O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 78824-30-3 |
| PubChem ID | 22245705 |
| InChI Key | KCODNOOPOPTZMO-UHFFFAOYSA-N |
| Smiles | O=C1C(C(C2=CC(O)=C(O)C=C2)=O)=C(O)[C@](C[C@H](C/C=C(C)/C)C(C)=C)([C@@]3=O)C[C@@H](C/C=C(C)/C)C(C)(C)[C@]31C/C=C(C)\C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Garcinol
参考文献 for Garcinol
参考文献是支持产品生物活性的出版物。
Ahmad et al (2012) Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells. Mol.Cancer.Ther. 11 2193 PMID: 22821148
Balasubramanyam et al (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J.Biol.Chem. 279 33716 PMID: 15155757
Nishino et al (2011) Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One 6 e24298 PMID: 21931675
按产品操作查看相关产品
关键词: Garcinol, Garcinol supplier, inhibitors, inhibits, histone, acetyltransferase, HAT, PCAF, p300, HSCs, EMT, MET, β-catenin, breast, cancer, hematopoietic, stem, cells, epithelial, to, mesenchymal, transition, Histone, Acetyltransferases, Stem, Cell, Proliferation, 4827, Tocris Bioscience
Garcinol 的评论
目前没有该产品的评论。 Be the first to review Garcinol and earn rewards!
Have you used Garcinol?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.