Gastrin I (human)

Cat. No. 3006 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective CCK₂ agonist

纯度： ≥95% (HPLC)

引用文献 (8)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Gastrin I (human)

Gastrin I (human) is an endogenous peptide produced in the stomach that acts as a selective CCK2 receptor agonist. Gastrin I stimulates gastric acid secretion and has a mitogenic effect on gastric cells. Gastrin I stimulates gastric epithelial cell proliferation and histamine secretion (EC₅₀ values are 6.2 pM and 0.014 nM, respectively). Gastrin I is also used in the culture of stomach, intestine and pancreas organoids. For more information about using Gastrin I in the generation of gastric organoids see the Human Gastric Organoid Culture Protocol.

技术数据 for Gastrin I (human)

分子量	2098.22
公式	C₉₇H₁₂₄N₂₀O₃₁S
序列	XGPWLEEEEEAYGWMDF (Modifications: X = Glp, Phe-17 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	10047-33-3
PubChem ID	16162108
InChI Key	GKDWRERMBNGKCZ-RNXBIMIWSA-N
Smiles	[H]N1[C@@H](CCC1=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Gastrin I (human)

溶解性	Soluble to 1 mg/ml in 1% Ammonia with sonication

产品说明书 for Gastrin I (human)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Gastrin I (human)

参考文献是支持产品生物活性的出版物。

Noble et al (1999) International union of pharmacology XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol.Rev. 51 745 PMID: 10581329

Blandizzi et al (1999) CCK1 and CCK2 receptors regulate gastric pepsinogen secretion. Eur.J.Pharmacol. 373 71 PMID: 10408253

Sato et al (2015) SnapShot: Growing Organoids from Stem Cells. Cell 161 1700 PMID: 26091044

Mahe et al (2014) Establishment of gastrointestinal epithelial organoids Curr.Protoc. Mouse Biol. 3 217 PMID: 25105065

Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148 126 PMID: 25307862

Kidd et al (2007) A comparison of the effects of gastrin, somatostatin and dopamine receptor ligands on rat gastric enterochromaffin-like cell secretion and proliferation. Regul.Pept. 143 109 PMID: 17531331

If you know of a relevant reference for Gastrin I (human), please let us know.

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关键词: Gastrin I (human), Gastrin I (human) supplier, Selective, CCK2, agonists, Cholecystokinin2, Receptors, GastrinI, (human), organoids, gastric, histamine, Receptor, Organoids, 3006, Tocris Bioscience

8 篇 Gastrin I (human) 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Gastrin I (human) 的部分引用包括：

Dings et al (2022) Estrogen-related receptor alpha drives mitochondrial biogenesis and resistance to neoadjuvant chemoradiation in esophageal cancer. Cell.Rep.Med. 3 100802 PMID: 36334593

He et al (2022) Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation. Cell Stem Cell 29 1333 PMID: 36002022

Post et al (2020) Snake venom gland organoids. Cell 180 233 PMID: 31978343

Somerville et al (2018) TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Cell Rep 25 1741 PMID: 30428345

Roe et al (2017) Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell 170 875 PMID: 28757253

Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148 126 PMID: 25307862

Colomer et al (2019) IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer. Mol Cell 75 669 PMID: 31302002

Filippini et al (2019) Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease. Sci Rep 9 12286 PMID: 31439856

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