Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGBR 12783 dihydrochloride is a very potent and selective inhibitor of dopamine uptake (IC50 for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).
分子量 | 485.5 |
公式 | C28H32N2O.2HCl |
储存 | Desiccate at -20°C |
纯度 | ≥99% (HPLC) |
CAS Number | 67469-75-4 |
PubChem ID | 24744862 |
InChI Key | HJDXBLLTRMCYNC-JFXLULTRSA-N |
Smiles | Cl[H].Cl[H].C(CN1CCN(C\C=C\C2=CC=CC=C2)CC1)OC(C1=CC=CC=C1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 24.27 | 50 |
以下数据基于产品分子量 485.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.5 mM | 4.12 mL | 20.6 mL | 41.19 mL |
2.5 mM | 0.82 mL | 4.12 mL | 8.24 mL |
5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
25 mM | 0.08 mL | 0.41 mL | 0.82 mL |
参考文献是支持产品生物活性的出版物。
Bonnet and Constentin (1986) GBR 12783, a potent and selective inhibitor of DA uptake: biochemical studies in vivo and ex vivo. Eur.J.Pharmacol. 121 199 PMID: 3754516
Do-Rego et al (1999) Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of DA. J.Neurochem. 72 396 PMID: 9886093
Giros et al (1992) Cloning, pharmacological characterization and chromosome assignment of the human DA transporter. Mol.Pharmacol. 42 383 PMID: 1406597
Vaugeois et al (1992) In vivo labelling of the neuronal DA uptake complex in the mouse striatum by [3H]GBR 12783. Eur.J.Pharmacol. 210 77 PMID: 1350989
If you know of a relevant reference for GBR 12783 dihydrochloride, please let us know.
关键词: GBR 12783 dihydrochloride, GBR 12783 dihydrochloride supplier, Potent, selective, dopamine, reuptake, inhibitors, inhibits, DAT, Dopamine, Transporters, Monoamine, Neurotransmitter, GBR12783, dihydrochloride, 0513, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 GBR 12783 dihydrochloride 的部分引用包括:
Ferraro et al (2012) A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology 37 1856 PMID: 22453136
Ferreira et al (2012) Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences. J Pharmacol Exp Ther 61 219 PMID: 22609378
Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769
Masi et al (2013) MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral DA neurons. Br J Pharmacol 169 130 PMID: 23323755
您是否知道使用了 Tocris GBR 12783 dihydrochloride 的优秀论文? 请告知我们.
平均评分: 4 (Based on 1 Review.)
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
DAT blocker GBR12783 (1 μΜ)
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.