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Submit ReviewGBR 12783 dihydrochloride
说明： Potent and selective DA uptake inhibitor
化学名： 1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride
纯度： ≥99% (HPLC)
生物活性 for GBR 12783 dihydrochloride
GBR 12783 dihydrochloride is a very potent and selective inhibitor of dopamine uptake (IC50 for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).
技术数据 for GBR 12783 dihydrochloride
| 分子量 | 485.5 |
| 公式 | C28H32N2O.2HCl |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 67469-75-4 |
| PubChem ID | 24744862 |
| InChI Key | HJDXBLLTRMCYNC-JFXLULTRSA-N |
| Smiles | Cl[H].Cl[H].C(CN1CCN(C\C=C\C2=CC=CC=C2)CC1)OC(C1=CC=CC=C1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GBR 12783 dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 24.27 | 50 |
制备储备液 for GBR 12783 dihydrochloride
以下数据基于产品分子量 485.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.12 mL | 20.6 mL | 41.19 mL |
| 2.5 mM | 0.82 mL | 4.12 mL | 8.24 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
| 25 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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产品说明书 for GBR 12783 dihydrochloride
参考文献 for GBR 12783 dihydrochloride
参考文献是支持产品生物活性的出版物。
Bonnet and Constentin (1986) GBR 12783, a potent and selective inhibitor of DA uptake: biochemical studies in vivo and ex vivo. Eur.J.Pharmacol. 121 199 PMID: 3754516
Do-Rego et al (1999) Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of DA. J.Neurochem. 72 396 PMID: 9886093
Giros et al (1992) Cloning, pharmacological characterization and chromosome assignment of the human DA transporter. Mol.Pharmacol. 42 383 PMID: 1406597
Vaugeois et al (1992) In vivo labelling of the neuronal DA uptake complex in the mouse striatum by [3H]GBR 12783. Eur.J.Pharmacol. 210 77 PMID: 1350989
If you know of a relevant reference for GBR 12783 dihydrochloride, please let us know.
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关键词: GBR 12783 dihydrochloride, GBR 12783 dihydrochloride supplier, Potent, selective, dopamine, reuptake, inhibitors, inhibits, DAT, Dopamine, Transporters, Monoamine, Neurotransmitter, GBR12783, dihydrochloride, 0513, Tocris Bioscience
4 篇 GBR 12783 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GBR 12783 dihydrochloride 的部分引用包括：
Ferraro et al (2012) A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology 37 1856 PMID: 22453136
Ferreira et al (2012) Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences. J Pharmacol Exp Ther 61 219 PMID: 22609378
Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769
Masi et al (2013) MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral DA neurons. Br J Pharmacol 169 130 PMID: 23323755
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GBR 12783 dihydrochloride 的评论
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Inhibition of Synaptic Transmission in the VP.
By
Anonymous on 02/02/2020
分析类型： In Vivo
种属： Mouse
DAT blocker GBR12783 (1 μΜ)
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