GBR 12783 dihydrochloride

Pricing Availability   Qty
说明: Potent and selective DA uptake inhibitor
化学名: 1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride
纯度: ≥99% (HPLC)
说明书
引用文献 (4)
评论 (1)
文献 (3)

生物活性 for GBR 12783 dihydrochloride

GBR 12783 dihydrochloride is a very potent and selective inhibitor of dopamine uptake (IC50 for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).

技术数据 for GBR 12783 dihydrochloride

分子量 485.5
公式 C28H32N2O.2HCl
储存 Desiccate at -20°C
纯度 ≥99% (HPLC)
CAS Number 67469-75-4
PubChem ID 24744862
InChI Key HJDXBLLTRMCYNC-JFXLULTRSA-N
Smiles Cl[H].Cl[H].C(CN1CCN(C\C=C\C2=CC=CC=C2)CC1)OC(C1=CC=CC=C1)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GBR 12783 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.27 50

制备储备液 for GBR 12783 dihydrochloride

以下数据基于产品分子量 485.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.12 mL 20.6 mL 41.19 mL
2.5 mM 0.82 mL 4.12 mL 8.24 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
25 mM 0.08 mL 0.41 mL 0.82 mL

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产品说明书 for GBR 12783 dihydrochloride

分析证书/产品说明书
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参考文献 for GBR 12783 dihydrochloride

参考文献是支持产品生物活性的出版物。

Bonnet and Constentin (1986) GBR 12783, a potent and selective inhibitor of DA uptake: biochemical studies in vivo and ex vivo. Eur.J.Pharmacol. 121 199 PMID: 3754516

Do-Rego et al (1999) Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of DA. J.Neurochem. 72 396 PMID: 9886093

Giros et al (1992) Cloning, pharmacological characterization and chromosome assignment of the human DA transporter. Mol.Pharmacol. 42 383 PMID: 1406597

Vaugeois et al (1992) In vivo labelling of the neuronal DA uptake complex in the mouse striatum by [3H]GBR 12783. Eur.J.Pharmacol. 210 77 PMID: 1350989


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关键词: GBR 12783 dihydrochloride, GBR 12783 dihydrochloride supplier, Potent, selective, dopamine, reuptake, inhibitors, inhibits, DAT, Dopamine, Transporters, Monoamine, Neurotransmitter, GBR12783, dihydrochloride, 0513, Tocris Bioscience

4 篇 GBR 12783 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GBR 12783 dihydrochloride 的部分引用包括:

Ferraro et al (2012) A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology 37 1856 PMID: 22453136

Ferreira et al (2012) Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences. J Pharmacol Exp Ther 61 219 PMID: 22609378

Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769

Masi et al (2013) MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral DA neurons. Br J Pharmacol 169 130 PMID: 23323755


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Inhibition of Synaptic Transmission in the VP.
By Anonymous on 02/02/2020
分析类型: In Vivo
种属: Mouse

DAT blocker GBR12783 (1 μΜ)

PMID: 29949769
review image

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