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Submit ReviewGBR 13069 dihydrochloride
说明： Potent dopamine uptake inhibitor
化学名： (1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
生物活性 for GBR 13069 dihydrochloride
GBR 13069 dihydrochloride is a potent inhibitor of dopamine uptake (IC50 = 40 nM). Centrally active following systemic administration in vivo.
技术数据 for GBR 13069 dihydrochloride
| 分子量 | 521.48 |
| 公式 | C28H30F2N2O.2HCl |
| 储存 | Desiccate at RT |
| CAS Number | 67469-45-8 |
| PubChem ID | 24978531 |
| InChI Key | ZBSZWEYIIGLGSX-RDRKJGRWSA-N |
| Smiles | FC(C=C2)=CC=C2C(OCCN3CCN(C/C=C/C4=CC=CC=C4)CC3)C1=CC=C(F)C=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GBR 13069 dihydrochloride
参考文献 for GBR 13069 dihydrochloride
参考文献是支持产品生物活性的出版物。
Heikkila et al (1984) Behavioural properties of GBR12909, GBR13069 and GBR13098: specific inhibitors of DA uptake. Eur.J.Pharmacol. 103 241 PMID: 6237922
Mayer et al (1986) Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport. J.Neurochem. 47 1073 PMID: 3489072
Van der Zee and Hespe (1985) Interaction between substituted 1-[2-diphenylmethoxyethyl]piperazines and DA receptors. Neuropharmacology 24 1171 PMID: 4094653
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关键词: GBR 13069 dihydrochloride, GBR 13069 dihydrochloride supplier, Potent, dopamine, reuptake, inhibitors, inhibits, DAT, Transporters, Monoamine, Neurotransmitter, GBR13069, dihydrochloride, Dopamine, 0420, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.