GC 1

Cat. No. 4554 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： High affinity thyroid receptor α (TRα) and TRβ agonist; thyromimetic

别名： Sobetirome

化学名： 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GC 1

GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (K_D values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T₃ in vitro at TRα₁ and TRβ₁ receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.

化合物库 for GC 1

GC 1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GC 1

分子量	328.4
公式	C₂₀H₂₄O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	211110-63-3
PubChem ID	9862248
InChI Key	QNAZTOHXCZPOSA-UHFFFAOYSA-N
Smiles	CC1=CC(OCC(O)=O)=CC(C)=C1CC2=CC(C(C)C)=C(O)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GC 1

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	16.42	50
	ethanol	16.42	50

制备储备液 for GC 1

以下数据基于产品分子量 328.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	6.09 mL	30.45 mL	60.9 mL
2.5 mM	1.22 mL	6.09 mL	12.18 mL
5 mM	0.61 mL	3.05 mL	6.09 mL
25 mM	0.12 mL	0.61 mL	1.22 mL

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产品说明书 for GC 1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GC 1

参考文献是支持产品生物活性的出版物。

Chiellini et al (1998) A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chem.Biol. 5 299 PMID: 9653548

Johansson et al (2005) Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc.Natl.Acad.Sci. U S A 102 10297 PMID: 16006512

Columbano et al (2006) The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 147 3211 PMID: 16574785

If you know of a relevant reference for GC 1, please let us know.

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