GeA-69

Cat. No. 6795 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective allosteric PARP14 inhibitor

化学名： N-[2-(9H-Carbazol-1-yl)phenyl]acetamide

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GeA-69

GeA-69 is a selective allosteric inhibitor of poly (ADP-ribose) polymerase 14 (PARP14) macrodomain 2 (MD2) (IC₅₀ = 720 nM, K_d = 860 nM). It inhibits adenosine diphosphate ribose (ADPR) binding to the macrodomain 2 of PARP14 and prevents PARP14 MD2 localization to DNA damage sites in intact cells. GeA-69 is highly cell permeable.

技术数据 for GeA-69

分子量	300.35
公式	C₂₀H₁₆N₂O
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2143475-98-1
PubChem ID	135397654
InChI Key	LDPDVNYCIOHPGF-UHFFFAOYSA-N
Smiles	O=C(NC=1C=CC=CC1C=2C=CC=C3C=4C=CC=CC4NC23)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GeA-69

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	30.03	100
	ethanol	15.02	50

制备储备液 for GeA-69

以下数据基于产品分子量 300.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.33 mL	16.65 mL	33.29 mL
5 mM	0.67 mL	3.33 mL	6.66 mL
10 mM	0.33 mL	1.66 mL	3.33 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

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产品说明书 for GeA-69

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GeA-69

参考文献是支持产品生物活性的出版物。

Schuller et al (2017) Discovery of a selective allosteric inhibitor targeting macrodomain 2 of polyadenosine-diphosphate-ribose polymerase 14. ACS Chem.Biol. 12 2866 PMID: 28991428

Moustakim et al (2018) Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Bioorg.Med.Chem. 26 2965 PMID: 29567296

If you know of a relevant reference for GeA-69, please let us know.

按标靶查看相关产品

关键词: GeA-69, GeA-69 supplier, GeA69, GeA, 69, PARP, inhibitors, inhibits, PolyADP, ribose, Polymerases, Poly(ADP, ribose), Polymerase, adenosine, diphosphate, ADPR, selective, MD2, macrodomain, 2, Poly(ADP-ribose), 6795, Tocris Bioscience

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