Gedunin

Name: Gedunin
Brand: Tocris Bioscience
SKU: 3387
Rating: 5 (1 reviews)

Cat. No. 3387 2 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Hsp90 inhibitor; exhibits anticancer and antimalarial activity

化学名： (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Gedunin

Gedunin is a naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC₅₀ values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Decreases ovarian cancer cell proliferation in vitro and may enhance cisplatin-induced reduction in proliferation (CAT.No 3387). Also exhibits antimalarial activity against Plasmodium falciparum (IC₅₀ values are 0.14 and 3.1 μM in parasite development and [³H]-hypoxanthine uptake assays respectively).

技术数据 for Gedunin

分子量	482.57
公式	C₂₈H₃₄O₇
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	2753-30-2
PubChem ID	12004512
InChI Key	YJXDGWUNRYLINJ-BHAPSIHVSA-N
Smiles	O=C4[C@@H]6[C@]3(O6)[C@]2(C)[C@H](OC(C)=O)C[C@@]1([H])C(C)(C)C(C=C[C@@](C)1[C@]([H])2CC[C@](C)3[C@H]([C@]5=COC=C5)O4)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Gedunin

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	48.26	100
	ethanol	4.83	10 温和加热

制备储备液 for Gedunin

以下数据基于产品分子量 482.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.36 mL	20.72 mL
5 mM	0.41 mL	2.07 mL	4.14 mL
10 mM	0.21 mL	1.04 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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产品说明书 for Gedunin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Gedunin

参考文献是支持产品生物活性的出版物。

Uddin et al (2007) Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytother.Res. 21 757 PMID: 17450509

Brandt et al (2008) Gedunin, a novel Hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. J.Med.Chem. 51 6495 PMID: 18816111

Lee et al (2008) Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine 15 533 PMID: 17913482

Kamath et al (2009) Gedunin, a novel natural substance, inhibits ovarian cancer cell proliferation. Int J Gynecol Cancer. 19 1564 PMID: 19955938

If you know of a relevant reference for Gedunin, please let us know.

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关键词: Gedunin, Gedunin supplier, Hsp90, inhibitors, inhibits, anticancer, antimalarial, activity, Heat, Shock, Protein, 90, Plasmodium, falciparum, Antimalarials, 3387, Tocris Bioscience

2 篇 Gedunin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Gedunin 的部分引用包括：

Yadav et al (2010) Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. J Mol Med (Berl) 88 1243 PMID: 20798912

Rizk et al (2015) Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites. PLoS One 10 e0125276 PMID: 25915529

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Gedunin 的评论

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Gedunin used to demonstrate anti-proliferative activity.

By Rutsha L Phillips on 12/14/2019

种属： Human

Gedunin used to demonstrate anti-proliferative activity against prostate cancer cell line. The depletion of cellular levels of Hsp90-dependent client proteins was scrutinised.

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