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GGsTop

Cat. No. 4452 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of γ-glutamyl transpeptidase (GGT)
化学名： 3-[[(3-Amino-3-carboxypropyl)methoxyphosphinyl]oxy]benzeneacetic acid
纯度： ≥95% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GGsTop

GGsTop is a selective, irreversible γ-glutamyl transpeptidase (GGT) inhibitor; displays no inhibitory effects on glutamine amidotransferases or asparagine synthetase. Suppresses oxidative stress by inhibiting GGT activation. Prevents ischemia/reperfusion-induced acute kidney injury in rats in vivo.

技术数据 for GGsTop

分子量 331.26
公式 C13H18NO7P
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 926281-37-0
PubChem ID 23582776
InChI Key NTFPDEDRMYYPAC-UHFFFAOYSA-N
Smiles NC(C(O)=O)CCP(OC1=CC=CC(CC(O)=O)=C1)(OC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GGsTop

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 6.63 20
DMSO 16.56 50

制备储备液 for GGsTop

以下数据基于产品分子量 331.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 6.04 mL 30.19 mL 60.38 mL
2.5 mM 1.21 mL 6.04 mL 12.08 mL
5 mM 0.6 mL 3.02 mL 6.04 mL
25 mM 0.12 mL 0.6 mL 1.21 mL

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产品说明书 for GGsTop

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for GGsTop

参考文献是支持产品生物活性的出版物。

Han et al (2007) Design, synthesis, and evaluation of γ-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of γ-glutamyl transpeptidase. Biochemistry 46 1432 PMID: 17260973

Yamamoto et al (2011) Preventive effect of GGsTop, a novel and selective γ-glutamyl transpeptidase inhibitor, on ischemia/reperfusion-induced renal injury in rats. J.Pharmacol.Exp.Ther. 339 945 PMID: 21937737

If you know of a relevant reference for GGsTop, please let us know.

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关键词: GGsTop, GGsTop supplier, GGsTop, GGT, inhibitors, inhibits, g-GGT, gamma-GGT, γ-GGT, glutamyltransferases, Glutamyl, Transpeptidase, Ischemia, ischaemia, oxidative, stress, Other, Transferases, 4452, Tocris Bioscience

2 篇 GGsTop 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GGsTop 的部分引用包括：

Elaine Y et al (2018) The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet. Cell 173 1728-1741.e13 PMID: 29804833

Kenji et al (2022) Rapid fluorescent vital imaging of olfactory epithelium. iScience 25 104222 PMID: 35494237

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