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Submit ReviewGGTI 297
说明： Geranylgeranyltransferase I (GGTase I) inhibitor
化学名： N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine trifluoroacetate salt
纯度： ≥95% (HPLC)
生物活性 for GGTI 297
Geranylgeranyltransferase I (GGTase-I) inhibitor (IC50 values are 135 and 418 nM for GGTase-I and FTase inhibition respectively). Inhibits RhoA prenylation leading to inactivation of RhoA/ROCK and a decrease in basal tone of the internal anal sphincter in vitro.
技术数据 for GGTI 297
| 分子量 | 579.63 |
| 公式 | C26H31N3O3S.CF3CO2H |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| PubChem ID | 90488779 |
| Smiles | SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@@](O)=O)CC(C)C)=O)C(C2=CC=CC3=C2C=CC=C3)=C1.FC(F)(F)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GGTI 297
参考文献 for GGTI 297
参考文献是支持产品生物活性的出版物。
Patel et al (2007) RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter. J.Pharmacol.Exp.Ther. 32 501 PMID: 17322025
Qian (1998) Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics. Bioorg.Med.Chem. 6 293 PMID: 9568283
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关键词: GGTI 297, GGTI 297 supplier, GGTI297, geranylgeranyltransferase-I, GGTase-I, geranyl, inhibitors, inhibits, FTase, RhoA, prenylation, ROCK, Protein, Prenyltransferases, 2774, Tocris Bioscience
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