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Submit ReviewGhrelin (human)
说明： Endogenous ghrelin receptor agonist
纯度： ≥95% (HPLC)
生物活性 for Ghrelin (human)
Ghrelin (human) is an endogenous agonist peptide for the ghrelin receptor (GHS-R1a). Produced mainly by the stomach, it stimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production.
许可信息
This peptide is distributed under license from Dr. Kangawa
技术数据 for Ghrelin (human)
| 分子量 | 3370.9 |
| 公式 | C149H249N47O42 |
| 序列 |
GSSFLSPEHQRVQQRKESKKPPAKLQPR (Modifications: Ser-3 = Ser(n-octanoyl)) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 258279-04-8 |
| PubChem ID | 16133832 |
| InChI Key | GNKDKYIHGQKHHM-RJKLHVOGSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](COC(=O)CCCCCCC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ghrelin (human)
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for Ghrelin (human)
参考文献 for Ghrelin (human)
参考文献是支持产品生物活性的出版物。
Inui (2001) Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat.Rev.Neurosci. 2 551 PMID: 11483998
Kojima et al (1999) Ghrelin is growth-hormone-releasing acylated peptide from stomach. Nature 402 656 PMID: 10604470
Tolle et al (2001) In vivo and in vitro effects of ghrelin/motilin-related peptide on GH secretion in the rat. Neuroendocrinology 73 54 PMID: 11174017
If you know of a relevant reference for Ghrelin (human), please let us know.
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关键词: Ghrelin (human), Ghrelin (human) supplier, Endogenous, ghrelin, receptor, agonists, GHS-R1a, Receptors, Growth, Hormone, Secretagog, Receptor, 1a, peptides, acylated, Ghrelin, 1463, Tocris Bioscience
3 篇 Ghrelin (human) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ghrelin (human) 的部分引用包括：
Bake et al (2018) Ghrelin's effects on food motivation in rats are not limited to palatable foods. J Neuroendocrinol e12665 PMID: 30525248
Bake et al (2017) Acute ghrelin changes food preference from a high-fat diet to chow during binge-like eating in rodents. J Neuroendocrinol 29 PMID: 28219000
Rodríguez et al (2009) Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. Sci Signal 33 541 PMID: 19238155
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.