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Gilteritinib

Cat. No. 7891 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent FLT3 inhibitor; also potently inhibits AXL
化学名： 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Gilteritinib

Gilteritinib is a potent Fms-like tyrosine kinase 3 (FLT3) and AXL inhibitor (IC50 = 0.29 nM and 0.73 nM, for FLT3 and AXL, respectively). In vivo, Gilteritinib reduces tumor growth and improves survival in xenograft and intra-bone marrow transplantation models of FLT3 mutated acute myeloid leukemia. Gilteritinib is orally bioavailable.

技术数据 for Gilteritinib

分子量 552.71
公式 C29H44N8O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1254053-43-4
InChI Key GYQYAJJFPNQOOW-UHFFFAOYSA-N
Smiles O=C(N)C=1N=C(C(=NC1NC2=CC=C(C(OC)=C2)N3CCC(N4CCN(C)CC4)CC3)NC5CCOCC5)CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Gilteritinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.53 10

制备储备液 for Gilteritinib

以下数据基于产品分子量 552.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 18.09 mL 90.46 mL 180.93 mL
0.5 mM 3.62 mL 18.09 mL 36.19 mL
1 mM 1.81 mL 9.05 mL 18.09 mL
5 mM 0.36 mL 1.81 mL 3.62 mL

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参考文献 for Gilteritinib

参考文献是支持产品生物活性的出版物。

Mori et al (2017) Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia. Invest.New Drugs 35 556 PMID: 28516360

If you know of a relevant reference for Gilteritinib, please let us know.

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关键词: Gilteritinib, Gilteritinib supplier, FLT3, AXL, inhibitors, inhibits, FMS-like, receptor, tyrosine, kinase-3, acute, myeloid, leukemia, xenograft, AML, orally, bioavailable, , in, vivo, 7891, Tocris Bioscience

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