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Submit ReviewGLPG 0187
说明： Potent αv integrin inhibitor
化学名： 3-[[2,5-Dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-L-alanine
纯度： ≥97% (HPLC)
生物活性 for GLPG 0187
GLPG 0187 is a potent αv integrin inhibitor (IC50 values are 1.2-3.7 nM). Inhibits osteoclastic bone resorption and angiogenesis in vitro and in vivo. Suppresses epithelial-mesenchymal transition (EMT) and migration of PC-3M-Pro4/luc cells, without inhibiting cell growth. Induces detachment and necrosis of GL-261 and SMA-560 murine glioma cells.
技术数据 for GLPG 0187
| 分子量 | 595.71 |
| 公式 | C29H37N7O5S |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 1320346-97-1 |
| PubChem ID | 53340771 |
| InChI Key | CXHCNOMGODVIKB-VWLOTQADSA-N |
| Smiles | O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC=C(OC)C=C5)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GLPG 0187
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 5.96 | 10 |
制备储备液 for GLPG 0187
以下数据基于产品分子量 595.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.79 mL | 83.93 mL | 167.87 mL |
| 0.5 mM | 3.36 mL | 16.79 mL | 33.57 mL |
| 1 mM | 1.68 mL | 8.39 mL | 16.79 mL |
| 5 mM | 0.34 mL | 1.68 mL | 3.36 mL |
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产品说明书 for GLPG 0187
参考文献 for GLPG 0187
参考文献是支持产品生物活性的出版物。
van der Horst, et al (2011) Targeting of αv-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. Neoplasia 13 516 PMID: 21677875
Silginer et al (2014) Integrin inhibition promotes atypical anoikis in glioma cells. Cell Death Dis. 5 e1012 PMID: 24457956
If you know of a relevant reference for GLPG 0187, please let us know.
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关键词: GLPG 0187, GLPG 0187 supplier, GLPG0187, αv, integrins, inhibitors, inhibitor, inhibits, inhibit, epithelial-mesenchymal, transition, EMT, osteoclastic, bone, resorption, Integrins, Cell, Adhesion, Molecules, 7059, Tocris Bioscience
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引用文献是使用了 Tocris 产品的出版物。
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GLPG 0187 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
