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Submit ReviewGNE 9278
说明： Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
化学名： 4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide
纯度： ≥98% (HPLC)
生物活性 for GNE 9278
GNE 9278 is a positive allosteric modulator of NMDA receptors. Potentiates NMDA receptors containing GluN2A, 2B, 2C and 2D subunits (EC50 values are 0.74, 3.07, 0.47 and 0.32 μM in a Ca2+ influx assay, respectively). Binds within the transmembrane domain and displays preference for agonist-bound NMDA receptors. Slows receptor deactivation and enhances the potency of glutamate and glycine.
化合物库 for GNE 9278
GNE 9278 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for GNE 9278
| 分子量 | 429.54 |
| 公式 | C21H27N5O3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 901230-11-3 |
| PubChem ID | 22432385 |
| InChI Key | OKXCVUICUUOADN-UHFFFAOYSA-N |
| Smiles | OC(N1C2=NC(CCC)=N1)=C(C(C)=N2)N[S](=O)(C3=CC=C(C4CCCCC4)C=C3)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GNE 9278
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 42.95 | 100 |
制备储备液 for GNE 9278
以下数据基于产品分子量 429.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.64 mL | 23.28 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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产品说明书 for GNE 9278
参考文献 for GNE 9278
参考文献是支持产品生物活性的出版物。
Wang et al (2017) A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. 121 204 PMID: 28457974
If you know of a relevant reference for GNE 9278, please let us know.
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关键词: GNE 9278, GNE 9278 supplier, GNE9278, NMDA, receptor, positive, allosteric, modulators, modulates, PAM, GluN2A, GluN2B, GluN2C, GluN2D, Receptors, 6369, Tocris Bioscience
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