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GoSlo SR 5-69

Cat. No. 5814 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： KCa1.1 (BK) channel activator
化学名： Sodium 1-Amino-9,10-dioxo-4-((5,6,7,8-tetrahydronaphthalen-2-yl)amino)-9,10-dihydroanthracene-2-sulfonate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GoSlo SR 5-69

GoSlo SR 5-69 is a BK channel activator (EC50 = 251 nM). Shifts the voltage required for half maximal negatively (DV1/2 = -104 mV).

技术数据 for GoSlo SR 5-69

分子量 470.47
公式 C24H19N2NaO5S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 1363419-31-1
PubChem ID 56944133
InChI Key JOJJZTFRBZWSBX-UHFFFAOYSA-M
Smiles NC1=C2C(C3=CC=CC=C3C(C2=C(C=C1S(=O)([O-])=O)NC4=CC=C5CCCCC5=C4)=O)=O.[Na+]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GoSlo SR 5-69

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.05 100

制备储备液 for GoSlo SR 5-69

以下数据基于产品分子量 470.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.63 mL 21.26 mL
5 mM 0.43 mL 2.13 mL 4.25 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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参考文献 for GoSlo SR 5-69

参考文献是支持产品生物活性的出版物。

Roy et al (2014) Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. Eur.J.Med.Chem. 75 426 PMID: 24561672

Schewe et al (2019) A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science 363 875 PMID: 30792303

If you know of a relevant reference for GoSlo SR 5-69, please let us know.

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关键词: GoSlo SR 5-69, GoSlo SR 5-69 supplier, GoSloSo5-69, SR569, BK, channels, activators, activates, Ca2+-Activated, Potassium, Channels, 5814, Tocris Bioscience

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