GPBAR-A

Cat. No. 4478 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： GPBA receptor (TGR5) agonist

化学名： 4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one

纯度： ≥98% (HPLC)

引用文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GPBAR-A

GPBAR-A is a gPBA receptor agonist. Upregulates GLP-1 secretion from intestinal cultures. Increases MQAE-fluorescence suggesting a decrease in intracellular chloride concentration in gallbladder epithelial cells.

技术数据 for GPBAR-A

分子量	484.37
公式	C₂₃H₁₅F₇N₂O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	877052-79-4
PubChem ID	11656002
InChI Key	ZIXNJVGTAXRKAP-UHFFFAOYSA-N
Smiles	O=C(CO3)N(CC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)CC1=C3N=CC=C1C2=C(F)C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GPBAR-A

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	48.44	100
	ethanol	9.69	20

制备储备液 for GPBAR-A

以下数据基于产品分子量 484.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.06 mL	10.32 mL	20.65 mL
5 mM	0.41 mL	2.06 mL	4.13 mL
10 mM	0.21 mL	1.03 mL	2.06 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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产品说明书 for GPBAR-A

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GPBAR-A

参考文献是支持产品生物活性的出版物。

Parker et al (2012) Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. Br.J.Pharmacol. 165 414 PMID: 21718300

Keitel et al (2009) The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 50 861 PMID: 19582812

If you know of a relevant reference for GPBAR-A, please let us know.

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关键词: GPBAR-A, GPBAR-A supplier, TGR5, agonists, g-protein, bile, acid, receptors, GPBA, GPBAR, Receptors, 4478, Tocris Bioscience

2 篇 GPBAR-A 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GPBAR-A 的部分引用包括：

Kowal et al (2015) Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells. Stem Cells Transl Med 13 28 PMID: 26050734

Bas et al (2021) A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium. Nat Commun 12 7159 PMID: 34887382

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Pathways for GPBAR-A

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.