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Submit ReviewGPP 78 hydrochloride
说明： NAMPT inhibitor; also induces autophagy
化学名： N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for GPP 78 hydrochloride
GPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.
技术数据 for GPP 78 hydrochloride
| 分子量 | 476.01 |
| 公式 | C27H29N5O.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 90488976 |
| InChI Key | WNZSQRVUGCAYDC-UHFFFAOYSA-N |
| Smiles | O=C(NC3=C(C4=CC=CC=C4)C=CC=C3)CCCCCCCN1N=NC(C2=CC=CN=C2)=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GPP 78 hydrochloride
参考文献 for GPP 78 hydrochloride
参考文献是支持产品生物活性的出版物。
Colombano et al (2010) A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J.Med.Chem. 53 616 PMID: 19961183
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关键词: GPP 78 hydrochloride, GPP 78 hydrochloride supplier, GPP78, hydrochloride, NMPRTase, NAMPT, NAD, nicotinamide, phosphoribosyltransferase, inhibitors, inhibits, autophagy, induces, inducers, Autophagy, 4835, Tocris Bioscience
1 篇 GPP 78 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GPP 78 hydrochloride 的部分引用包括：
Fons et al (2019) PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun 10 3790 PMID: 31439867
GPP 78 hydrochloride 的评论
平均评分: 5 (Based on 1 Review.)
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Great inhibitor..
By
Anonymous on 05/07/2020
分析类型： In Vitro
种属： Human
细胞系/组织： human astrocytes
After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.
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