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GPR52 Comp-43

Cat. No. 7445 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： GPR52 receptor antagonist
化学名： (2E)-5-Phenyl-1-(2-thienyl)-2-penten-1-one
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GPR52 Comp-43

GPR52 Comp-43 is a GPR52 receptor antagonist (IC50 = 0.63 μM). The use of GPR52 Comp-43 in animal models of Huntington's Disease leads to degradation and reduction of soluble and aggregated mutant huntingtin protein in the striatum. It also reduces neuronal loss, promotes neuronal survival and improves motor functions in vivo. GPR52 Comp-43 is active in vitro and brain penetrant.

技术数据 for GPR52 Comp-43

分子量 242.34
公式 C15H14OS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1239987-91-7
PubChem ID 156588927
InChI Key XUIAIACHIPOOHR-BJMVGYQFSA-N
Smiles O=C(C1=CC=CS1)/C=C/CCC2=CC=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GPR52 Comp-43

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.23 100
ethanol 24.23 100

制备储备液 for GPR52 Comp-43

以下数据基于产品分子量 242.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.13 mL 20.63 mL 41.26 mL
5 mM 0.83 mL 4.13 mL 8.25 mL
10 mM 0.41 mL 2.06 mL 4.13 mL
50 mM 0.08 mL 0.41 mL 0.83 mL

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参考文献 for GPR52 Comp-43

参考文献是支持产品生物活性的出版物。

Wang et al (2021) GPR52 antagonist reduces huntingtin levels and ameliorates Huntington's disease-related phenotypes. J.Med.Chem. 64 941 PMID: 33185430

Komatsu (2021) Discovery of the first druggable GPR52 antagonist to treat Huntington's disease. J.Med.Chem. 64 938 PMID: 33443413

If you know of a relevant reference for GPR52 Comp-43, please let us know.

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关键词: GPR52 Comp-43, GPR52 Comp-43 supplier, GPR52comp43, receptors, antagonists, antagonism, huntingtons, huntingtin, neuronal, GPCR, CAY10786, GPR52IN43, Orphan, 7-TM, Receptors, 7445, Tocris Bioscience

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