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Submit ReviewGR 135531
说明： High affinity melatonin MT3 ligand
别名： 5-MCA-NAT
化学名： 5-Methoxycarbonylamino-N-acetyltryptamine
纯度： ≥97% (HPLC)
生物活性 for GR 135531
Binds with high affinity to MT3 melatonin sites in hamster brain, and low affinity (and no efficacy) at MT1 and MT2 melatonin receptors and thus can be used to discriminate between the melatonin receptor subtypes.
技术数据 for GR 135531
| 分子量 | 275.31 |
| 公式 | C14H17N3O3 |
| 储存 | Store at RT |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 190277-13-5 |
| PubChem ID | 4284525 |
| InChI Key | MPZVHKLZCUEJFO-UHFFFAOYSA-N |
| Smiles | COC(=O)NC1=CC=C2NC=C(CCNC(C)=O)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GR 135531
参考文献 for GR 135531
参考文献是支持产品生物活性的出版物。
Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083
Lucchelli et al (1997) Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br.J.Pharmacol. 121 1775 PMID: 9283717
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关键词: GR 135531, GR 135531 supplier, High, affinity, melatonin, MT3, ligands, Receptors, GR135531, 5MCANAT, 5-MCA-NAT, Melatonin, (MT), 0896, Tocris Bioscience
5 篇 GR 135531 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GR 135531 的部分引用包括：
Loma et al (2015) Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability. J Neurosci 172 1045 PMID: 25297531
Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. Br J Pharmacol 336 127 PMID: 20959363
Crooke et al (2013) Melatonin and its analog 5-methoxycarbonylamino-N-acetyltryptamine potentiate adrenergic receptor-mediated ocular hypotensive effects in rabbits: significance for combination therapy in glaucoma. J Pharmacol Exp Ther 346 138 PMID: 23591996
Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179 PMID: 21091649
Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Pharmacol Exp Ther 108 625 PMID: 11518737
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