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Submit ReviewGR 46611
说明： 5-HT1D agonist
化学名： 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide
生物活性 for GR 46611
GR 46611 is a 5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands.
许可信息
Sold with the permission of GlaxoSmithKline
技术数据 for GR 46611
| 分子量 | 377.49 |
| 公式 | C23H27N3O2 |
| 储存 | Store at RT |
| CAS Number | 185259-85-2 |
| PubChem ID | 6160690 |
| InChI Key | LBVZWEWTNUDWNS-YRNVUSSQSA-N |
| Smiles | O=C(/C=C/C2=CC=C(NC=C3CCN(C)C)C3=C2)NCC1=CC=C(OC)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GR 46611
分析证书目前不在网上提供。
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参考文献 for GR 46611
参考文献是支持产品生物活性的出版物。
Clitherow et al (1994) Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J.Med.Chem. 37 2253 PMID: 8057272
Skingle et al (1994) Stimulation of central 5-HT1D receptors causes hypothermia in the guinea pig. J.Psychopharmacol. 8 14
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关键词: GR 46611, GR 46611 supplier, 5-HT1D, agonists, Serotonin, Receptors, GR46611, GlaxoSmithKline, GSK, 0864, Tocris Bioscience
1 篇 GR 46611 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GR 46611 的部分引用包括：
Gu et al (2007) Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury. J Urol 177 2381 PMID: 17509363
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.