5-HT1D Receptors

Serotonin 5-HT1D receptors, previously known as 5-HT1Dα receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in neuropsychiatric disorders such as depression.

Products
Background
Literature (1)
Gene Data

5-HT1D Receptor Agonists

Cat. No. Product Name / Activity
1985 PNU 142633
Highly selective 5-HT1D agonist
3586 Sumatriptan succinate
5-HT1A, 5-HT1B and 5-HT1D agonist
4657 Zolmitriptan
Potent 5-HT1B/1D/1F agonist

5-HT1D Receptor Antagonists

Cat. No. Product Name / Activity
1477 GR 127935 hydrochloride
Potent and selective 5-HT1B and 5-HT1D antagonist
3078 LY 310762 hydrochloride
Selective 5-HT1D antagonist

Serotonin 5-HT1D receptors, previously known as 5-HT1Dα receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in neuropsychiatric disorders such as depression.

External sources of pharmacological information for 5-HT1D Receptors :

Literature for 5-HT1D Receptors

Tocris offers the following scientific literature for 5-HT1D Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

5-HT1D Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR1D NM_000864 P28221
Mouse Htr1d NM_008309 Q61224
Rat Htr1d NM_012852 P28565